Men from all over the world are looking for the perfect remedy that will allow them to have a stone-like erection. Patients who are faced with the need to improve potency or treat erectile dysfunction may be confused when making a choice from a variety of pills. Several effective drugs are offered on the market. Therefore, you may want to clearly understand the difference between them. Stendra and Cialis are popular pharmaceuticals for improving male erectile function. Let’s highlight their features and significant differences.

Stendra (Avanafil): main characteristics

Stendra is a pill to eliminate problems with an erection. It contains PDE5 inhibitor avanafil. This is a newcomer to the PDE5i family, because it appeared in pharmacies after the approval of the FDA and EMA in 2012 and 2013, respectively.

The main active agent works by specific inhibiting enzyme phosphodiesterase type 5, which is located mainly in the corpora cavernosa. This leads to cGMP level elevation (in the cavernous bodies of the penis), so the substance boosts hence the flow of blood to penile tissues. A strong erection is the obvious outcome of these processes.

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Stendra has two important features. First, it has a high degree of selectivity. Its effect in relation to PDE5 is hundreds of times higher than in relation to other known PDEs (this figure can reach 10,000 times, when it comes to PDE1 and PDE9). Secondly, the chemical structure of the active substance provides fast and complete adsorption in the body. This significantly accelerates the onset pf positive effect after taking the medication.

The recommended dosage of the drug is 100 mg. Changing the standard dose may be possible only after doctor’s consultation.

Please note that Stendra improves erection, but does not trigger it. Studies have shown that efficaciousness of this drug is associated with sexual stimulation and arousal.

Cialis (Tadalafil): Key Features

Cialis is a drug for males with difficulty in achieving and maintaining a penile erection sufficient for intercourse. It is based on active component tadalafil. This is one of the highly selective PDE5 inhibitors.

Like in case of previously reviewed medication, tadalafil’s action is associated with relaxation of the smooth muscles of arteries. This leads to better blood flow to the penile tissues.

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Tadalafil is an old-timer on the market. The first clinical trials of this substance took place in 1991. After that, tadalafil-based drugs underwent hundreds of studies and refinements. Lilly ICOS LLC application for Cialis approval was sanctioned by the FDA in 2003.

The classic dosage for Cialis is 10 mg. The choice of the right tablet strength should be entrusted to a specialist. To save money, some men choose a 20-mg amount and then split the tablet.

A related topic: Splitting Pills – A Good Way To Cut Expenses On Medications

Higher dosages are typically used on demand to combat ED symptoms, while lower ones may be administered daily to treat impotence solely or in combination with benign prostatic hypertrophy.

What to choose: Stendra or Cialis

The selected drugs are similar in many respects, because they feature almost identical mechanism of action (except their specificity, which may differ). The principle of action in both cases is based on PDE5 suppression and cGMP level enhancement. Both drugs are eliminated mainly by the liver, because they are available in tablets for oral administration.

However, the chemical properties of the active substances have some differences that determine the nature of effect in the human body.

What is More Effective?

Stendra (avanafil) is characterized by a high rate of interaction with plasma proteins. The maximum concentration of avanafil is achieved within 30-45 minutes after intake. This means that the pill may kick in as soon as in 15 minutes. Abundant intake of fatty foods can double the waiting time. Taking pills is directly related to the planned sexual activity.

Duration of effect is directly proportional to the half-life of the active substance. It is about 6 hours. This time can sometimes reach 17 hours, which, however, has little effect on the period of peak action.

Cialis (tadalafil) reaches a maximum concentration within 2 hours. Many men feel the desired effect within 30 minutes after ingestion.

Unlike Stendra, Cialis lasts up to 36 hours. Therefore, experts (and pharma regulators) consider it acceptable for daily use. In addition, tadalafil is less sensitive to food intake, therefore, its rate of absorption is not changed (or altered minimally) after heavy meals.

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Which One is Safer?

Both sexual enhancers have a number of contraindications and side effects that should be taken into account.

Examples of Stendra’s side effects include:

  • headache
  • face flushing
  • nasal congestion

Some of widespread potential side effects of Cialis:

  • headache
  • dyspepsia
  • backache

Contraindications for taking avanafil:

  • severe liver failure
  • heart attack within less than 6 months prior to initiating the ED therapy
  • unstable angina pectoris
  • nitrate-based treatment

Contraindications for taking tadalafil:

  • severe cardiovascular diseases (when sexual activity is inadvisable)
  • renal or liver failure
  • concomitant intake of nitrates

The similar nature of the pharmacological action causes both drugs to have pretty similar adverse events and contraindications. The degree of their safety does not have big differences for the average person without chronic diseases.

Stendra vs Cialis: Comparison Summary

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The correct choice of a drug for the effective treatment of erectile dysfunction can only be made under guidance of a healthcare professional, who is aware about pharmacological properties of the medication and knows about all the features of the body of a particular patient. Both drugs are popular among men, but Cialis is more known. This medication may be preferable for those who wish to have better spontaneity in relationships and are able to consume the pill on an everyday basis.

Summing up, the key aspects when choosing between two market leaders include price, tolerability of their active components, and goals of treatment.

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