Drug Information: Indications, Side Effects, Warnings
Category: Â Women’s Health, Antifungals
Generic Gyne-Lotrimin is used to treat yeast (fungus) infections of the vagina.
Pharmacological groups: antifungals
Other synthetic antibacterials
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Nosological classification (ICD-10):
N76 Other inflammatory diseases of the vagina and vulva
Structure and Composition:
1 vaginal tablet contains 100 mg of clotrimazole; Blister of 6 pcs., complete with applicator.
1 g of a vaginal cream – 10 mg; in tubes of 50 g
Pharmacological action – a broad spectrum antifungal, trihomonatsidnoe, antiprotozoal, antifungal, anti-fungal, anti-bacterial.
Causes changes in the walls of the fungus, inhibits the synthesis of sterols bacteria, trichomonads and leads to their death.
Indications of the drug:
Vulvovaginal candidiasis, Trichomonas vaginitis.
Fungal skin and mucous membranes: ringworm, tinea, trichophytosis, athlete, microsporia, candidiasis, a fungal interdigital erosion, fungal paronychia; mycoses complicated by secondary pyoderma; pityriasis versicolor, erythrasma; thrush; candidal vulvitis, vulvovaginitis, balanitis, trichomoniasis; for the rehabilitation of the birth canal before delivery.
Hypersensitivity to clotrimazole.
Pregnancy and breast-feeding:
Not contraindicated in II and III trimester of pregnancy (data on the use in the I-trimester absent).
Vaginal irritation, burning sensation, skin rash, erythema, cramping abdominal pain, frequent urination, intercurrent cystitis, as well as burning and irritation of the genital organs of a partner.
Dosage and administration:
Intravaginally (tablets should be entered as far as possible). 1 table. per day for 6 days or Table 2. 3 consecutive days.
Vaginal cream, the recommended dose – full applicator once (preferably at bedtime) daily for 6-14 days.
Not recommended for use during menstruation. To prevent re-infection should be treated at the same time sexual partner (cream).
How it works:
– Violates the synthesis of ergosterol (the main structural component of the cell membrane of fungi)
– Changes the permeability of the membrane of the fungus
– Promotes the release of cells potassium intracellular phosphorus compounds
– Facilitates the disintegration of cellular nucleic acids.
– Inhibits the synthesis of triglycerides and phospholipids.
– Reduces activity of oxidative enzymes and peroxidase
– The intracellular concentration of hydrogen peroxide is increased to toxic levels. This contributes to the destruction of cellular organelles, leading to cell necrosis.
– Depending on the concentration, exhibits fungicidal or fungistatic effect.
– Inhibits the transformation of Candida albicans blastospores into invasive mycelial form.
Reduces the activity of (relative) polyene antibiotics (amphotericin B, nystatin, natamycin).
How to apply?
Topically with urogenital infections:
When candidiasis or balanitis vulvitis: used 2-3 times per day for 1-2 weeks.
For the treatment of trichomoniasis vaginitis in adults and adolescents: Vaginal tablet (500 mg dose or 200 mg for three days or 6-7 days, 100 mg, 1 times a day, in the evening). You can use cream (full applicator), which is introduced as deeply as possible into the vagina 1 time a day (at night).
For the preparation of the birth canal is recommended single administration of the tablet.
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