Drug Information: Indications, Side Effects, Warnings
Category: Womens health, Alzheimers and parkinsons
Generic Dostinex is used for treating disorders associated with high levels of the hormone prolactin, either due to tumors in the pituitary gland or to unknown causes.
Brand(s): Caberlin / Cabgoolin
Manufacturer: Sun Pharma
Dopamine receptor agonist
Nosological classification (ICD-10):
D35.2 Benign neoplasm of pituitary
N91.2 Amenorrhoea, unspecified
N91.5 unspecified oligomenorrhea
N97.0 Female infertility associated with lack of ovulation
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Generic Dostinex (Cabergoline) is a dopaminergic ergoline derivative and is characterized by severe and prolonged prolactin-reducing action.
Indications of the drug:
-To prevent physiological lactation after giving birth;
– For suppression of already established postpartum lactation;
– In the treatment of treatment of disorders associated with hyperprolactinemia, including diseases such as amenorrhea, oligomenorrhea, anovulation, galactorrhea;
-with the treatment of pituitary adenomas (micro – and makroprolaktinomy); – The indication is also: idiopathic hyperprolactinemia; syndrome empty sella in conjunction with hyperprolactinemia.
– Hypersensitivity to cabergoline or other components of the drug, as well as any ergot alkaloids;
– Children up to age 16 years (safety and efficacy in this group of patients has not been established).
Tell your doctor about the following diseases and conditions, if you have them: hypertension on the background of pregnancy, preeclampsia or post-partum hypertension; severe cardiovascular disease, Raynaud’s syndrome; peptic ulcer.
Tell your doctor about gastrointestinal bleeding; severe hepatic impairment (we recommend the use of lower doses).
It is important to pay attention to the severe psychotic or cognitive impairment (including in history); symptoms of dysfunction of the heart and respiration due to fibrotic changes or the presence of such states in history.
Prohibited the simultaneous application of drugs, has a hypotensive effect (due to the risk of orthostatic hypotension).
Pregnancy and breast-feeding:
If the pregnancy during treatment, the doctor may stop taking the medication.
In other cases, use of the drug during pregnancy may be only on strict conditions.
The most frequent side effects are presented below.
From the CCC: palpitations; rarely – orthostatic hypotension (with prolonged use – hypotensive effect); possibly asymptomatic decrease in blood pressure during the first 3-4 days after birth.
From the nervous system: common: dizziness / vertigo, headache, fatigue; can be: drowsiness, depression, fatigue; cases were: paresthesia, syncope.
From the digestive system: common: nausea, vomiting, epigastric pain. It Can be: abdominal pain, constipation, gastritis, dyspepsia.
Other side effects: mammalgia, epistaxis. Often: rush of blood to the face, transient hemianopsia. Maybe: angiospasms fingers and muscle spasms of the lower limbs.
In women with amenorrhea may be a reduction in hemoglobin level for the first several months after restoration of menstruation.
Other side effects that may include: alopecia, elevated blood creatinine phosphokinase, mania, dyspnea.
Patients should pay attention to: edema, fibrosis, liver function abnormalities and abnormalities in liver function tests. Should be under control: hypersensitivity reactions, rash, respiratory disorder, respiratory failure, valvulopatiya.
Symptoms of overdose include nausea, vomiting, diarrhea disorders.
- orthostatic hypotension, confusion, psychosis, hallucinations.
Treatment: supporting activities aimed at the elimination of the drug (gastric lavage) and, if necessary, to maintain blood pressure. Your doctor may prescribe receiving dopamine antagonists.
The use of cabergoline causes drowsiness. The use of dopamine receptor agonists may cause a sudden sleep in patients with Parkinson’s disease.
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