Danocrine (Danazol)

Drug Information: Indications, Side Effects, Warnings

Category: antiallergic, womens health

Generic Danocrine affects the ovaries and pituitary gland and prevents the release of certain hormones in the body. It is used to treat endometriosis and fibrocystic breast disease. It is also used to prevent attacks of angioedema in people with an inherited form of this disorder.

Brand(s): Danogen / Gynazolcheap Danocrine

Manufacturer: Cipla / Sun Pharma

Pharmacological action:

Inhibitor of gonadotropin-releasing hormone products.

Inhibits proliferation and causes atrophy of normal and ectopic endometrial tissue.

Reduces the loss of menstrual blood, this mechanism of action is not clear.


Dose, dosing frequency and duration of treatment is determined individually.

Pregnancy and lactation:

Contraindicated during pregnancy and lactation.

Side effects:

From the Endocrine: amenorrhea, flushing, increased sweating, reducing the size of the breast, changes in libido, vaginitis, emotional lability, nervousness, acne, increased secretion of the sebaceous glands, slight hirsutism, edema, weight gain, deepening of the voice, androgenic alopecia, disturbances of spermatogenesis.

From the digestive system: dysfunction of the gastrointestinal tract, increase in liver enzymes; rarely – cholestatic jaundice.

Central nervous system: possible headache, dizziness, tremor, depression, fatigue, sleep disorders; rarely – a small increase in intracranial pressure.

Hematopoietic system: an increase or decrease in the number of blood cells.

Dermatological reactions: skin rash.

Metabolism: giperglyukagonemiya, impaired glucose tolerance, increased serum concentrations of LDL cholesterol, decrease in serum concentrations of HDL cholesterol.

Cardio-vascular system: rarely – tachycardia, hypertension.

Others: back pain, muscle spasms or cramps; rarely – visual impairment.


Indications for use:

Endometriosis with concomitant infertility, benign tumors of the breast (fibrocystic breast disease), primary menorrhagia, premenstrual syndrome, gynecomastia; hereditary angioedema.


Serious liver and / or kidney disease, chronic heart failure, porphyria, thromboembolic disorders (including history), androgenozavisimye tumor, vaginal bleeding of unknown origin, breast cancer, cancer, pregnancy, lactation, hypersensitivity to Danazol .

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