Drug Information: Indications, Side Effects, Warnings
Actigall (Ursodiol (ursodeoxycholic))
Category:Â Urinary Tract
Generic Actigall is used for treating and preventing gallstones.
Generic Actigall has choleretic, cholelitolitic, lipid-lowering, cholesterol-lowering and some immunomodulatory effects.
The drug dissolves cholesterol gallstones and prevents the formation of new stones.
Sorbet from the small intestine. Plasma protein binding is high – up to 96-99%.
Metabolized in the liver.
Indications for use of the drug:
– Uncomplicated gallstone disease: biliary sludge; dissolution of cholesterol gallstones in the gallbladder, prevention of stone recurrence after cholecystectomy;
-chronic active hepatitis;
–Â Toxic (including drugs) liver disease;
–Â Alcoholic liver disease;
–Â Primary biliary cirrhosis;
-primary sclerosing cholangitis;
-cystic fibrosis (cystic fibrosis) of the liver;
-atresia of the intrahepatic bile ducts (including congenital atresia of the bile duct);
-biliary reflux gastritis and reflux esophagitis;
-biliary dyspeptic syndrome (with holetsistopatii and biliary dyskinesia);
-prevention of liver damage while using hormonal contraceptives and cytostatic.
The capsules of the drug are taken orally, drinking plenty of water.
From the digestive system: nausea, vomiting, diarrhea (may be dose-related), constipation, transient increase in liver transaminases; rarely – calcination gallstones.
Others: back pain, allergic reactions, exacerbation of Pre-existing psoriasis, alopecia; rarely – calcination gallstones.
Contraindications to the use of Generic Actigall:
– Gallstones are high in calcium;
-not functioning gall bladder;
– Acute cholecystitis;
– Acute cholangitis;
-cirrhosis of the liver decompensation;
-acute infectious disease of the gallbladder and bile ducts;
-empyema of the gallbladder;
– Hypersensitivity to the drug.
Use of the drug in the human liver:
Contraindicated in hepatic insufficiency.
Use of the drug in renal impairment:
Contraindicated in patients with renal insufficiency.
Overdoses ursodeoxycholic acid is not known.
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