Drug Information: Indications, Side Effects, Warnings
Category:Â Hypertension, Cardiovascular Diseases
Generic Diovan is used for treating high blood pressure alone or with other medicines. It is also used for treating heart failure in patients who do not tolerate angiotensin-converting enzyme (ACE) inhibitors.
Brand(s): Valen / Diovan / Valzaar
Manufacturer: Lupin / Novartis / Torrent
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Angiotensin II receptor antagonists
Composition, structure and packing
Tablets, coated yellow, oval, with beveled edges, on one side of risk and extruded inscription “DO”, on the other side – “NVR”.
Specific antagonist of angiotensin II. Selectively blocking receptor subtype AT1, which are responsible for the known effects of angiotensin II. The consequence of AT1-receptor blockade is to increase the plasma concentrations of angiotensin II, which may stimulate the unblocked AT2-receptors.
Indications for use:
– Chronic heart failure (II-IV functional class classification NYHA) in patients receiving standard therapy, including diuretics, digitalis and ACE inhibitors or beta-blockers (not simultaneously). The use of all these drugs is not mandatory;
– To improve the survival of patients with acute myocardial infarction complicated by left ventricular failure and / or left ventricular systolic dysfunction, the presence of stable hemodynamics.
– Hypersensitivity to the drug.
Precautions: with bilateral renal artery stenosis, stenosis of the artery to a solitary kidney, with a diet with restriction of sodium, with conditions accompanied by a decrease in the bcc (including diarrhea, vomiting), and hepatic failure with obstruction of the biliary tract, renal insufficiency (creatinine clearance less than 10 ml / min) (in t. h. patients on hemodialysis).
Infections and infestations: common – viral infections; sometimes – infections of the upper respiratory tract, pharyngitis, sinusitis, fatigue; very rarely – rhinitis.
Hematopoietic system: often – neutropenia; very rarely – thrombocytopenia.
Immune system: very rarely – hypersensitivity reactions, including serum sickness.
CNS: often – postural golovokruzhenie2; sometimes – vertigo, obmorok1, insomnia, decreased libido; rarely – golovokruzhenie4; very rarely – headache bol4.
Cardio-vascular system: often – orthostatic gipotenziya2; sometimes – gipotenziya1,4 arterial, cardiac nedostatochnost1; very rarely – vasculitis.
The respiratory system: sometimes – cough.
From the digestive system: rarely – diarrhea, abdominal pain; very rarely – toshnota4.
Dermatological reactions: very rarely – angioneurotic otek3; rash, itching.
On the part of the musculoskeletal system: sometimes – pain in the back; very rarely – arthralgia, myalgia.
From the urinary system: very rarely – pochek3,4 dysfunction, acute renal nedostatochnost3, renal nedostatochnost3.
Other: rarely – fatigue, asthenia, edema, giperkaliemiya1,2.
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