Drug Information: Indications, Side Effects, Warnings
Generic Diovan HCT is used for treating high blood pressure.
Composition, structure and packing
Tablets, film-coated light orange, oval, biconvex, marked “NGN” on one side and “CG” – on the other.
Other ingredients: colloidal anhydrous silica, crospovidone, magnesium stearate, microcrystalline cellulose.
The composition of the shell: hypromellose, macrogol 8000, talc, titanium dioxide (E171), iron oxide red (E172), iron oxide yellow (E172).
Antihypertensive drug, which consists of angiotensin II receptor antagonist and a thiazide diuretic.
Active hormone of the renin-angiotensin-aldosterone system (RAAS) is an angiotensin II.
Co-Diovan appoint 1 tab. 1 time / day every day. Depending on the clinical situation, the recommended daily dose is one tablet of 80 / 12.5 mg tablet or 1 160 / 12.5 mg. If necessary, appoint 1 tablet 160/25 mg.
Symptoms: severe hypotension.
-if the drugwasrecently adopted, shouldinduce vomiting.
– Intravenous saline.
With a frequency of less than 1%: abdominal pain, blurred vision, anxiety, arthralgia, arthritis, bronchitis, dyspepsia, dyspnea, impotence, insomnia, muscle spasms of the lower limbs, frequent urination, palpitations, rash, sprains, urinary tract infections, viral infections , edema, asthenia, vertigo. The causal relationship of these phenomena with the use of Diovan Hct has not been established.
Rare: angioedema, rash, pruritus, and other hypersensitivity reactions / allergic reactions including serum sickness, and vasculitis. In some cases: renal dysfunction.
From the laboratory parameters: in 2.2% of patients in the serum potassium concentration decreased by more than 20% (a decrease of this indicator in the group of patients treated with placebo was 3.3%). In controlled clinical trials in 1.4% of patients had an increase in serum creatinine concentration (compared to 1.1% for the group of patients receiving placebo).
In monotherapy: with a frequency of more than 1% – arthralgia; with a frequency of less than 1% – swelling, fatigue, insomnia, rash, decreased libido, vertigo. Often – urticaria, and other rash, loss of appetite, nausea and vomiting, postural hypotension (severity of which increases with the consumption of alcohol, use of anesthesia or sedatives), impotence. Rarely – photosensitivity, abdominal pain, constipation, diarrhea, discomfort in the digestive tract, intrahepatic cholestasis, jaundice, arrhythmias, headache, dizziness, sleep disturbances, depression, paresthesia, visual disturbances, thrombocytopenia, sometimes with purpura. Very rare – necrotizing vasculitis, toxic epidermal necrolysis, lupus reactions, exacerbation of cutaneous manifestations of systemic lupus erythematosus, pancreatitis, leukopenia, agranulocytosis, inhibition of bone marrow hematopoiesis, hemolytic anemia, hypersensitivity reactions, disorders of the respiratory system (including pneumonitis and pulmonary edema). There are water-electrolyte and metabolic disturbances.
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