Instructions for use, contraindications, composition and price of Nexium

Nexium reduces amount of acid in the stomach and helps patients with gastroesophageal reflux disease and Zollinger-Ellison syndrome. Active ingredient: Esomeprazole

The nosological classification (ICD-10) of Nexium

K21.0 Gastro-oesophageal reflux with oesophagitis
K25 Gastric ulcer
K26 Duodenal Ulcer
K31.8.2 * gastric hyperacidity
K86.8.3 * Zollinger-Ellison Syndrome
K92.2 Gastro-intestinal bleeding, unspecified
Y45 adverse reactions in therapeutic use of analgesic, antipyretic and anti-inflammatory agents



The drug forms of Nexium

Tablets 20 mg: oblong biconvex, light pink, film-coated, engraved with “20 mg» on one side and «A / EH» – on the other.

Tablets 40 mg: oblong biconvex, pink, film-coated, engraved with “40 mg» on one side and «A / EI» – on the other.

Color on a break – white with yellow patches (cereal type).

Indications for use of Nexium

gastroesophageal reflux disease:

– Treatment of erosive reflux esophagitis;

– Long-term maintenance therapy after healing of erosive reflux esophagitis to prevent relapse;

– Symptomatic treatment of gastroesophageal reflux disease;

gastric ulcer and duodenal ulcer (in a combination therapy):

– Treatment of duodenal ulcer associated with Helicobacter pylori;

– Prevention of relapse of peptic ulcers associated with Helicobacter pylori;

long-term therapy in patients undergoing bleeding from peptic ulcers (after / in the use of drugs, reducing the secretion of gastric glands) for relapse prevention;

Patients taking NSAIDs for a long time:

– Healing of gastric ulcers associated with NSAID;

– Prevention of gastric and duodenal ulcers associated with NSAIDs, in patients at risk;

Zollinger-Ellison syndrome and other conditions characterized by pathological hypersecretion of gastric glands, including idiopathic hypersecretion.



Contraindications of Nexium

Hypersensitivity to esomeprazole, substituted benzimidazoles or other ingredients included in the formulation;

hereditary fructose intolerance, glucose-galactose malabsorption or sucrase-izomaltaznaya failure;

concomitant use with atazanavir and nelfinavir (see “Interaction”.);

Children up to age 12 years (due to lack of data on efficacy and safety of the drug in this patient group);

children older than 12 years (for other indications, except gastroesophageal reflux disease).

Precautions: severe renal insufficiency (application experience is limited).

Side effects of Nexium

The frequency of side effects is given by the following grading: very common (≥1 / 10); commonly (≥1 / 100, <1/10); uncommon (≥1 / 1000, <1/100); rare (≥1 / 10,000, <1/1000); very rare (<1/10000).

Skin and subcutaneous tissue disorders: uncommon – dermatitis, pruritus, rash, urticaria; rare – alopecia, photosensitivity; very rarely – erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

On the part of the musculoskeletal and connective tissue disorders: rarely – arthralgia, myalgia; rarely – muscle weakness.

From the nervous system: often – headache; Infrequent – dizziness, paresthesia, drowsiness; rarely – a violation of taste.

Mental disorders: rarely – insomnia; rarely – depression, agitation, confusion; very rarely – hallucinations, aggressive behavior.

On the part of the digestive tract: often – abdominal pain, constipation, diarrhea, flatulence, nausea / vomiting; Infrequent – dry mouth; rarely – stomatitis, gastrointestinal candidiasis; very rarely – microscopic colitis.

On the part of the liver and biliary tract: rarely – increase in liver enzymes; rarely – hepatitis (with or without jaundice); very rarely – liver failure, encephalopathy in patients with liver disease.

From the genitals and breast: it is very rare – a gynecomastia.

From the blood and lymphatic system: rarely – leukopenia, thrombocytopenia; very rarely – agranulocytosis, pancytopenia.

Immune system: rarely – hypersensitivity reactions (eg fever, angioedema, anaphylactic reaction / anaphylactic shock).

The respiratory system, organs, thoracic and mediastinal disorders: rarely – bronchospasm.

On the part of the kidney and urinary tract: very rarely – interstitial nephritis.

On the part of the organ of vision: rarely – blurred vision.

On the part of metabolism and nutrition: rarely – peripheral edema; rarely – hyponatremia; very rarely – hypomagnesemia; hypocalcemia due to severe hypomagnesemia, hypokalemia, hypomagnesemia due.

General disorders: rarely – malaise, sweating.