Micronase: Indications for use, Contraindications, Dosage and taking

Micronase contains glyburide, which lowers glucose levels in the blood.

Indications for use

Diabetes mellitus type 2 (with the poor diet). Combination therapy with insulin daily to control blood glucose levels.


Hypersensitivity, diabetes mellitus type 1 (including in childhood and adolescence), diabetic ketoacidosis, diabetic precoma and coma, hyperosmolar coma, microangiopathy, liver and / or renal failure, extensive burns, trauma, major surgery, intestinal obstruction , gastroparesis, a condition accompanied by disturbance of food intake and the development of hypoglycemia (infectious diseases), leukopenia, pregnancy, lactation. Feverish syndrome, alcoholism, adrenal insufficiency, thyroid disease (hypothyroidism or hyperthyroidism).



Dosage and taking

Size of the dose depends on the age, severity of diabetes, blood glucose (fasting and two hours after a meal). The average daily dose of from 2.5 to 15 mg. Multiplicity of reception: 1-3 times a day for 20-30 minutes before eating. The starting dose in elderly patients – 1 mg / day.

Side effects

Hypoglycaemia (in violation of the dosing and inadequate diet regime); weight gain, fever, arthralgia, proteinuria, allergic reactions (skin rash, itching), dyspepsia (nausea, diarrhea, feeling of heaviness in the epigastric), neurological disorders (paresis, sensory disturbances), violations of hematopoiesis (hypoplastic or hemolytic anemia, leukopenia, agranulocytosis, pancytopenia, eosinophilia, thrombocytopenia), hepatic dysfunction (cholestasis), late cutaneous porphyria, changes in taste, polyuria, photosensitivity, headache, fatigue, weakness, dizziness.


Symptoms: hypoglycemia (hunger, sweating, severe weakness, palpitations, tremor, anxiety, headache, dizziness, insomnia, irritability, depression, cerebral edema, impaired speech and vision, impaired consciousness), hypoglycemic coma.

Treatment: If the patient is conscious, take sugar by mouth, with loss of consciousness – in / enter dextrose (in / bolus – a 50% dextrose solution, then infusion of 10% solution), 1-2 mg of glucagon n / a, / m or w / w, 30 mg of diazoxide in / for 30 min, the concentration of glucose control through each 15 minutes, and determination of pH, BUN, creatinine, electrolytes in the blood. After regaining consciousness necessary to give the patient foods rich in carbohydrate (to avoid a recurrence of hypoglycemia). If swelling of the brain – mannitol and dexamethasone.