Starlix (nateglinide) is an oral diabetes medicine that helps control blood sugar levels.
Oral hypoglycemic agents
Composition of Starlix
Main ingredient: nateglinide – 60 mg
Excipients: lactose monohydrate, microcrystalline cellulose, povidone, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide (E171), talc, macrogol, colloidal anhydrous silica, iron oxide red (E172).
Nateglinide, unlike other oral hypoglycemic agents, insulin secretion is expressed (within the first 15 minutes after ingestion). Thus, oscillations are smoothed postprandial (“spikes”) in the blood glucose concentration.
Indications for use Starlix
Starlix (nateglinide) is an oral diabetes medicine that helps control blood sugar levels. Starlix helps your body respond better to insulin produced by your pancreas.
-saharny type 2 diabetes (non-insulin dependent) – when poor diet and physical activity.
Starliks can be applied as a monotherapy, or in combination with hypoglycemic agents with a different mechanism of action, for example, metformin.
Nateglinide – a potent substance that is a major component of the Starlix drug. Get emergency medical help if you have any of these signs of an allergic reaction to Starlix: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Contraindications of Starlix
Do not use Starlix if you are allergic to nateglinide, if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
– type 1 diabetes (insulin-dependent);
-liver function abnormalities (in the absence of clinical trial data for this patient population);
-children’s age (in the absence of clinical data for this age group of patients);
-Increased sensitivity to the drug.
Dosage of Starlix
Starliks should be taken before meals. The time interval between taking the drug and food intake should not exceed 30 minutes. Typically, the drug is taken just before eating.
On the part of metabolism: after the appointment of nateglinide as the use of other hypoglycemic drugs, the symptoms were observed, presumably indicating the development of hypoglycemia, such as sweating, tremor, dizziness, increased appetite, palpitations, nausea, fatigue, malaise. Typically, these events is weak and easily stoped taking carbohydrates were expressed. According to clinical studies, the concentration of glucose in the blood of less than 3.3 mmol / L occurred in 2.4% of those patients who have the above clinical manifestations were observed.
Other: rarely – increased levels of liver enzymes in the blood (typically poorly marked and transient); hypersensitivity reactions (rash, pruritus, urticaria).
Overdose of Starlix
Cases of overdose have not been described.
Symptoms of hypoglycemia with clinical manifestations of varying severity.
Treatment: The treatment strategy is determined by the severity of the symptoms of hypoglycemia. Shows a typical glucose / sugar solution inside as well as dose correction and / or meals. When severe hypoglycemia accompanied by neurological symptoms (coma, convulsions), shown in / in a glucose solution. The use of dialysis to remove blood from a nateglinide inefficient due to its high plasma protein binding.