Mevacor is a medication to lower cholesterol levels in patients with primary hypercholesterolemia.
The nosological classification (ICD-10):
E78.0 Pure hypercholesterolaemia
E78.2 Mixed hyperlipidaemia
I25.1 Atherosclerotic heart disease
Structure and Composition
1 tablet contains lovastatin 10, 20 or 40 mg; in blister 14 pcs., in box 2 of the blister.
The drug reduces total cholesterol, LDL, VLDL and triglycerides; increases HDL in blood serum.
Indications for use
Primary hypercholesterolemia (hypolipoproteinaemias IIa and IIb type) with high LDL (the ineffectiveness of diet therapy in patients at increased risk of coronary atherosclerosis), combined hypercholesterolemia and hypertriglyceridemia, atherosclerosis.
Hypercholesterolemia (primary, combined with hypertriglyceridemia); coronary atherosclerosis.
Hypersensitivity, liver disease in the active phase, continuous unexplained elevation of serum transaminases.
Flatulence, nausea, vomiting, dyspepsia, diarrhea (or constipation), abdominal pain, dry mouth, taste disorders, anorexia, hepatitis, jaundice; dizziness, headaches, sleep disorders, psychiatric disorders, anxiety, paresthesia, cramps, myalgia, myopathy (requiring discontinuation of the drug), allergic reactions (anaphylactoid, angioedema, polymyalgia rheumatica, thrombocytopenia, leukopenia, hemolytic anemia, arthralgia, asthenia, photosensitivity, flushing , chills, rash, hives and others.).
From the digestive system: heartburn; rarely – nausea, diarrhea, constipation, flatulence, dry mouth, taste disturbances, anorexia, increase in liver transaminases in blood, in rare cases – cholestatic jaundice, hepatitis, pancreatitis, gastralgia, abnormal liver function.
From the musculoskeletal system: myalgia, myopathy, myositis, rhabdomyolysis (with simultaneous application of cyclosporine, gemfibrozil, or niacin), arthralgia, elevated noncardiac fraction of CK in the blood plasma.
From the central and peripheral nervous system: dizziness, headache, sleep disorders, convulsions, paresthesia; in rare cases – personality disorders.
From hemopoiesis system: hemolytic anemia, leukopenia, thrombocytopenia.
On the part of the organ of vision: blurred vision, cataract, cataracts, and optic atrophy.
Allergic reactions: skin rash, itching; in rare cases – urticaria, angioedema, toxic epidermal necrolysis.
Other: decreased potency; acute renal failure (due to rhabdomyolysis), chest pain, palpitations.