Mestinon is used to treat myasthenia gravis

Mestinon is used to treat myasthenia gravis or intestinal atony and atonic constipation, it works increasing muscle tone of smooth muscles in different organs.

Indications for use

Myasthenia gravis; myasthenic syndrome; post-operative intestinal atony, atonic constipation, bladder atony, trauma-induced movement disorders; flaccid paralysis; residual effects of polio, encephalitis; violation of emptying the bladder after gynecological operations and childbirth; cessation of muscle relaxation during general anesthesia; overdose of nondepolarizing muscle relaxants; intoxication anticholinergic drugs (with the prevalence of peripheral symptoms).



The active substance and the group

Pyridostigmine (Pyridostigmine bromide), anticholinesterase agents

Dosage Form

injection, tablets


1. Hypersensitivity, prior to receiving depolarizing muscle relaxants (suxamethonium, decamethonium); iritis, COPD, asthma, obstructive ileus, a spasm of the gastrointestinal tract, biliary and urinary tract, myotonia, Parkinson’s disease, thyrotoxicosis, postoperative shock crises, lactation.

2. Hypotension, heart failure, acute myocardial infarction, peptic ulcer and 12 duodenal ulcer, diabetes, gastrointestinal surgery, pregnancy.

Method of use and dosage

Inside, in / m, intravenously, orally.

When intestinal atony, atonic constipation, inside, 60 mg, with an interval of 4 hours;

in acute myasthenia – at 60-180 mg, 2-4 times a day;

if necessary – to increase the dose.

Parenteral – 5 mg, up to 5 times per day.

To stop miorelaxation: in / slow 5 mg Mestinon (sometimes in combination with 0.5 mg of atropine).

When poisoning with anticholinergic drugs: – slow intravenous or / m, 3-5 mg.

Pharmacologic effect

Anticholinesterase agents;

It improves neuromuscular transmission, increases gastrointestinal motility, increases the tone of the bladder, bronchial secretion of exocrine glands; cause bradycardia, it causes a slight miosis, spasm of accommodation.

Side effects

Nausea, vomiting, diarrhea, stomach cramps, increased peristalsis, hypersecretion of bronchial glands, salivation, lacrimation, frequent urination, decreased blood pressure, bradycardia, miosis; convulsions, muscle twitching, myasthenia gravis.

Skin rashes (due to content in the preparation of bromine) Overdose. Symptoms: increased secretion of the lacrimal, salivary and sweat glands, skin redness, severe weakness, blurred vision, cramps, dizziness, nausea, vomiting, involuntary defecation and urination, intestinal colic, bronchospasm, pulmonary edema, severe or progressive myasthenia, paralysis of the respiratory muscles, decrease in blood pressure, collapse, bradycardia, paradoxical tachycardia or cardiac arrest.

Treatment: / slow atropine sulfate – 1.2 mg (if necessary – again after 2-4 hours, depending on the heart rate), restoration and maintenance of vital functions.