Naprelan : User, application and side-effect

Naprolen is used to treat pain and inflammation in such conditions as arthritis, tendinitis, bursitis, ankylosing spondylitis, gout or menstrual cramps.

The nosological classification (ICD-10) of Naprelan

J06 Acute upper respiratory infections of multiple and unspecified

K08.8.0 * Pain tooth

M06.9 Rheumatoid arthritis, unspecified

M08.0 Juvenile rheumatoid arthritis

M10.0 Idiopathic gout

M19.9 Arthritis, unspecified

M45 Ankylosing spondylitis

M54.1 Radiculopathy

Unspecified M77.9 Enthesopathy

M79.1 Myalgia

M79.2 Neuralgia and neuritis, unspecified

M89.9 bone disease, unspecified

And oophoritis N70 Salpingitis

N94.4 Primary dysmenorrhoea

R50 Fever of unknown origin

R51 Headache

Unspecified R52.9 Pain

T14.9 Injury, unspecified

Z100 * CLASS XXII Surgical practice



Pharmacology of Naprelan

Mode of action – anti-inflammatory, analgesic, antipyretic, antiagregatine.

Indications for use of Naprelan

Inflammatory and degenerative diseases of the musculoskeletal system, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, articular syndrome in exacerbation of gout, juvenile rheumatoid arthritis; pain: neuralgia, myalgia, ossalgia, sciatica, headache and tooth pain, tendonitis, pain in cancer, postoperative pain, accompanied by inflammation, trauma of the musculoskeletal system and soft tissue, adnexitis, primary dysmenorrhea; pain and fever in infectious and inflammatory diseases of the upper respiratory tract (in the complex therapy).

Contraindications of Naprelan

Hypersensitivity, aspirin asthma, “Aspirin” triad (a combination of asthma, recurrent nasal polyposis, and paranasal sinuses and intolerance of aspirin and drugs pirazolonovogo series), erosive and ulcerative lesions of the gastrointestinal tract in the acute phase of the breach of blood, liver and / or kidney failure, children up to 1 year.

Before using the medication please consult with your doctor to avoid overdose Naprelan and not cause a complication of the disease.

Side effects of Naprelan

The side effects most commonly encountered in clinical trials (possibly associated with the use of naproxen)

From the digestive tract: 3-9% – heartburn, abdominal pain, nausea, constipation; > 1% – diarrhea, dyspepsia, stomatitis; <1% – bloating, bleeding / perforation, gastrointestinal ulcer (gastroduodenal), vomiting, increase in liver transaminases. From the nervous system and sensory organs: 3-9% – headache, drowsiness, dizziness, tinnitus, visual impairment, hearing impairment; > 1% – vertigo.

Cardio-vascular system and blood (blood, hemostasis):> 1% – heart rate; <1% – anemia, increased bleeding time.

From the respiratory system: 3-9% – dyspnea.

For the skin: 3-9% – ecchymosis.

With the genitourinary system: <1% – renal dysfunction. Allergic reactions: 3-9% – itching, skin rash, anaphylactoid reaction. Other: 3-9% – edema; > 1% – increased sweating, purpura, thirst.

Adverse events occurred at a frequency <1% in clinical trials and post-marketing studies (possibly associated with the use of naproxen)

From the digestive tract: colitis, hematemesis, jaundice, pancreatitis, melena.

With the genitourinary system: glomerular nephritis, hematuria, hyperkalemia, interstitial nephritis, nephrotic syndrome, renal failure, renal papillary necrosis.

Cardio-vascular system and blood (blood, hemostasis): agranulocytosis, eosinophilia, granulocytopenia, leukopenia, thrombocytopenia.

From the nervous system and sensory organs, depression, abnormal dreams, inability to concentrate, insomnia, malaise, myalgia, muscle weakness.

Adverse events occurred at a frequency <1% (causal relationship to the use of naproxen is not installed):

Cardio-vascular system and blood (blood, hemostasis): aplastic anemia, hemolytic anemia.

From the nervous system and sensory organs: aseptic meningitis, cognitive dysfunction.

From the digestive tract: ulceration gastrointestinal tract, ulcerative stomatitis.

Allergic reactions: epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome, urticaria; photosensitivity reaction.

Others: Vasculitis, hyper / hypoglycemia, alopecia, foto dermatitis.