Popular antifungal antibiotics
One of the most popular antifungal antibiotics is Nizoral. The reading for its usage, is most of fungal infections, which are common in human, such as candidiasis, blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis, or paracoccidioidomycosis. Nizoral is assigned for both external and systematic treatments of various fungal infections. Nizoral is one of the best preparations in the category of Anti Fungal medications.
Manufacturer: Medichrom â€“ GREECE
Clinico-pharmacological group: antifungal medication
Composition, structure and packing: Tablets are white, round, flat, with beveled edge and etchings “JANSSEN” on one side and “TO 200” on another one.
Keep in a dry place at room temperature. Expiration date – 5 years.
Basic ingredient: 1 tab. 200 mg ketoconazole. The main active ingredient of the drug formulation is ketoconazole.
Other ingredients: corn starch – 80 mg, lactose monohydrate – 19 mg, polyvidone K90 – 6.6 mg, microcrystalline cellulose – 3 mg, colloidal silicon dioxide – 0.7 mg of magnesium stearate – 0.7 mg, purified water (removed during the manufacturing process).
The composition of the coating film: White tablets contain 200 mg of ketoconazole in multiples of 10 or 30 tablets in blisters. Other ingredients: water, corn starch, cellulose, lactose, polyvidone K90, magnesium stearate, colloidal silicon dioxide. Preparation synthesis slows and alters the composition of the components of the cell membrane of fungi, stopping their growth leads to death of pathogenic organisms.
1 tab. 200 mg ketoconazole, excipients.
Dosage: Nizoral drug is taken orally with meals to improve absorption.
Against infections of the skin, scalp and mucous membranes, which caused by dermatophytes and/or yeasts and systemic infections:
Adults: 1 tablet (200 mg), 1 per day with meals. If after this dose, the improvement does not occur, the dose should be doubled (400 mg, 1 time per a day). Over the vaginal candidiasis the dose should be 2 tab. (400 mg), 1 time per a day with meals.
Children elder than 3 years, with weight 15 to 30 kg: 1/2 tablet (100 mg), 1 time per a day (as the experience of the medicine to children with the weight less than 15 kg, is limited, the medicine is not recommended for children with the weight less than 15 kg ); for children with a body weight over 30 kg, the dose is indicated as for adults.
The average duration of cure
Vaginal candidiasis – 7 days;
Cutaneous mycoses caused by dermatophytes – about 4 weeks;
Multi-colored shingles – 10 days;
Candidiasis of the skin and mouth – 2-3 weeks;
Fungal scalp – 1-2 months;
Paracoccidioidomycosis, histoplasmosis, coctsidiodomikoz – duration of treatment is usually 6 months.
For all indications, the cure should be carried out continuously until clinical and laboratory parameters are not indicative of bacterial eradication. Inadequate duration of cure may lead to the recurrence of infection. However, when the signs and symptoms of hepatitis, such as anorexia, nausea, vomiting, fatigue, jaundice, abdominal pain and dark urine appear, you should immediately discontinue the treatment and check liver function in laboratory.
The most widespread symptoms of overdose are: nausea (27.2%), fatigue, including drowsiness and lethargy (14.2%), vomiting (12.6%), abdominal pain (12.0%), anorexia, including weight loss, loss of appetite (7.4%), congestion, including increased sweating (6.3%), edema (5.7%), gynecomastia (4.8%), skin rashes, including eczema, purpura, dermatitis (3.3%), diarrhea (2.2%), headache (2.0%), dysgeusia (1.3%), alopecia (1.1%).
In case of overdose, the condition of the patient and his symptomatic treatment should be closely monitored. Throughout the first hour after ingestion the preparation, the activated carbon can be assigned. If necessary, the gastric washing can be carried out.
Increased intracranial pressure;
Violation of the chair;
Very rarely development of drug-induced hepatitis is celebrated;
Photosensitivity (sensitivity to light);
Paresthesia (numbness, tingling, goose);
As a result of the fall in testosterone levels can gynecomastia in men and decreased libido;
Reducing the number of platelets.
Indications for use: Ketoconazole is used in the treatment of fungal infections, including treatment of fungal infections of the gastrointestinal tract, including
the esophagus and intestines;
treatment of chronic yeast infection, especially if the local media do not help;
mycosis feet, nails and other body parts.
Actual against fungus at an advanced stage;
prevention of fungal infections after chemotherapy.
For the treatment of skin and nails, the pills prescribed by a doctor, in special cases, such as if the patient has advanced age, or problems with immunity.
lactose intolerance, lactase deficiency;
age up to 3 years;
intolerance of any components of the formulation.
Contraindicated with concomitant use of such drugs:
In the concomitant taking with alcohol, the risk of side and toxic effects on the liver significantly increases.
Tablets containing clotrimazole, which are contraindicated for use during pregnancy and lactation.
If there is an urgent need to use the medication during breast feeding, you should discuss the interrupt timing of lactation during treatment with your doctor.
Where to buy? Nizoral is accessible to buy at a pharmacy or to order online.