Drug Information: Indications, Side Effects, Warnings
Generic Desyrel is used for treating depression.
Nosological classification (ICD-10):
F13 Mental and behavioral disorders due to use of sedatives or hypnotics
F32 depressive episode
F33 Recurrent depressive disorder
F41.2 Mixed anxiety and depressive disorder
F52.0 Lack or loss of sexual desire
R52 Pain, not elsewhere classified
Z50.2 Rehabilitation in alcoholism
Z50.3 Rehabilitation of Drug Addiction
Thiazolopyridine derivative; the chemical structure is not a tricyclic, tetracyclic antidepressants or other groups. Trazodone hydrochloride is a white, crystalline powder, soluble in water. The molecular weight is of 408.33.
Relieves mental (emotional tension, anxiety, insomnia) and somatic (palpitations, headache, myalgia, frequent urination, sweating) manifestations of anxiety. Increases the depth and duration of sleep in patients with depression, restores the physiological structure of sleep. It reduces the craving for alcohol.
Indications for use:
Depression of various etiologies (endogenous, psychotic, neurotic, Somatogenic et al.) With marked anxiety, tension; pain in neuralgia, agoraphobia, alcohol withdrawal state, drug dependence to benzodiazepines, decreased libido, impotence.
Hypersensitivity, myocardial infarction (early recovery period), ventricular arrhythmia, extrasystoles, tachycardia, hepatic and / or renal failure, age 6 years.
Hypertension (may require adjustment of doses of antihypertensive drugs), a history of priapism, age 18 years.
Pregnancy and breast-feeding:
Should not be applied to pregnant women.
From the nervous system and sensory organs: fatigue, weakness, headache, dizziness, insomnia, somnolence, agitation, psychosis, hypomania, hallucinations, tremor, muscle twitching, large seizures (grand mal), aphasia, ataxia, akathisia, dyskinesia, paresthesia, confusion, syncope, blurred vision, diplopia.
Cardio-vascular system and blood (blood, hemostasis): hypotension, including orthostatic; atrial fibrillation, arrhythmia (including tachy and bradycardia, ventricular ectopic beats), congestive heart failure, leukocytosis or leukopenia, neutropenia (usually small), hemolytic anemia, methemoglobinemia.
From the digestive tract: increased appetite, dry and unpleasant taste in the mouth, salivation, dental caries, periodontal disease tissues, oral candidiasis, nausea, vomiting, bloating, diarrhea, constipation, cholestasis, increased bilirubin, and amylase in the blood plasma, jaundice.
With the genitourinary system: urinary retention, frequent urination, hematuria, premature menses, hirsutism, increased libido, priapism, impotence, retrograde ejaculation.
Allergic reactions: skin rash, urticaria.
Other: myalgia, chest pain, alopecia, psoriasis, edema.
Symptoms: nausea, vomiting, drowsiness, dizziness, decreased blood pressure, loss of coordination, priapism, epileptiform seizures, ECG changes, respiratory arrest, weighting adverse reactions.
Treatment: gastric lavage, forced diuresis, administration of activated charcoal, maintenance of vital functions, symptomatic therapy. No specific antidote.
Inside. Adults: initial dose – 50-100 mg, once before bedtime, if necessary, increase the dose to 50 mg / day every 3-4 days to achieve a therapeutic effect. The maximum daily dose in an outpatient setting is 450 mg, stationary – 600 mg. For elderly and debilitated patients the initial dose of 100 mg / day, if necessary, can be increased to 300 mg / day. Children 6-18 years: of 1.5-2 mg / kg / day, if necessary to increase the dose of 6 mg / kg / day.
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