Drug Information: Indications, Side Effects, Warnings
Category: Â Urinary Tract, Antibiotics
Generic Furadantin is used for treating and preventing urinary tract infections caused by certain bacteria.
Broad spectrum antimicrobial action, nitrofuran derivative. Has bacteriostatic and bactericidal action in infections of the urinary tract. Nitrofurantoin is active against Escherichia coli, Klebsiella spp., Enterobacter spp., Proteus spp.
It is Effective mainly urinary tract infections.
Well absorbed from the gastrointestinal tract. Bioavailability is 50% (food increases bioavailability). The rate of absorption depends on the size of the crystals (microcrystalline form is characterized by rapid dissolution and absorption rate, shorter time to reach Cmax in the urine). Relationship to plasma proteins is 60%. It is metabolized in the liver and muscle tissue. T1 / 2 are 20-25 minutes. It is Penetrates the GEB, placental barrier, excreted in breast milk. Derived entirely by the kidneys (30-50% – unchanged).
Pregnancy and lactation:
Nitrofurantoin (Generic Furadantin) is contraindicated during pregnancy and lactation (breastfeeding).
The respiratory system: Frequent: chest pain, cough, dyspnea, pulmonary infiltrates, eosinophilia, interstitial pneumonitis or fibrosis. Sometimes it is: the decline in respiratory function, bronchial asthma attack in patients with a history of asthma. Inform your doctor.
From the digestive system: common: epigastric discomfort, anorexia, nausea, vomiting; rarely – hepatitis, cholestatic jaundice, abdominal pain, diarrhea. Require a dose adjustment.
CNS and peripheral nervous system: Sometimes: peripheral neuropathy, headache, nystagmus, dizziness, drowsiness. You should consult a physician.
Hematopoietic system: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, megaloblastic anemia (these changes are reversible). Tell your doctor about your symptoms.
Allergic reactions: Common: urticaria, angioedema, pruritus, rash; very rarely – anaphylactic shock. Require replacement drug.
Dermatological reactions: exfoliative dermatitis, erythema multiforme. Tell your doctor about adverse reactions.
Other: drug fever, arthralgia, flu-like symptoms are possible, superinfection urinary tract, often caused by Pseudomonas aeruginosa.
Indications for use:
Infectious-inflammatory diseases of the urinary tract (including pyelonephritis, cystitis) caused by susceptible microorganisms to nitrofurantoin.
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Expressed disturbances of renal excretory function, renal failure, oliguria, lack of glucose-6-phosphate dehydrogenase, pregnancy, early childhood (up to 1 month), hypersensitivity to nitrofurantoin, heart failure stage II-III, liver cirrhosis, chronic hepatitis, acute porphyria, lactation.
The risk of developing peripheral neuropathy is increased in patients with anemia, diabetes, electrolyte imbalance, lack of B vitamins B, renal insufficiency.
Nitrofurantoin should not be used to treat diseases of cortical kidney, prostate and purulent paranephritis. It is contraindicated in combination with drugs that cause renal dysfunction.
In renal impairment:
Contraindications impaired renal excretory function, renal failure, oliguria. The risk of developing peripheral neuropathy is increased in patients with severe renal insufficiency.
In hepatic dysfunction:
Contraindicated in hepatic cirrhosis, chronic hepatitis.
Application of childhood:
Contraindicated in early childhood (up to 1 month).
Prices for 75-280 ml 25mg/5ml of genericÂ nitrofurantoin oral suspension
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