Drug Information: Indications, Side Effects, Warnings
Description of the active substance :
solution for infusion, film-coated tablets
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The antimicrobial agent of the fluoroquinolone group, bactericidal effect. Exhibit activity against a broad spectrum of gram-positive and gram-negative microorganisms, anaerobic, and atypical acid-fast bacteria: Mycoplasma spp., Chlamydia spp., Legionella spp. Effective against bacterial strains resistant to beta-lactam antibiotics and macrolides. It is active against most strains of microorganisms: Gram positive – Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes (Group A); Gram – Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Escherichia coli, Enterobacter cloacae; atypical – Chlamydia pneumoniae, Mycoplasma pneumoniae. Studies in vitro have demonstrated that moxifloxacin resistance develops slowly in a series of sequential mutations. Between the drugs of the fluoroquinolones observed cross-resistance. However, some Gram-positive and anaerobic microorganisms resistant al. Fluoroquinolones sensitive to moxifloxacin. Do not have a photosensitizing action.
Infections of the upper and lower respiratory tract infections: acute sinusitis, acute exacerbations of chronic bronchitis, community-acquired pneumonia; infections of skin and soft tissue.
Hypersensitivity, age 18 years, epilepsy, severe diarrhea, pregnancy, lactation. Convulsions (in history), hepatic failure (group C on the scale of Child-Pyuga), prolongation of the interval QT; bradycardia, myocardial ischemia, concomitant use of drugs that slow conduction of the heart (including antiarrhythmics class Ia, II, III, tricyclic antidepressants, antipsychotics); Patients on hemodialysis (the lack of experience of application); diarrhea, pseudomembranous colitis; concomitant use of corticosteroids.
Often – 1-10%, rarely – 0.1-1%, extremely rare – 0.01-0.1%. From the digestive system: often – abdominal pain, dyspepsia (including flatulence, nausea, vomiting, constipation, diarrhea), increased activity of “liver” transaminases; rarely – dry mouth, candidiasis of the oral mucosa, anorexia, stomatitis, glossitis, increased gamma-glutamintransferazy; rarely – gastritis, tongue discoloration, dysphagia, transient jaundice. From the nervous system: often – dizziness, headache; rarely – fatigue, insomnia or drowsiness, nervousness, anxiety, tremor, paresthesias; rarely – hallucinations, depersonalization, increased muscle tone, poor coordination of movements, agitation, amnesia, aphasia, emotional lability, sleep disorders, speech disorders, disorders of cognitive processes, hypoesthesia, seizures, confusion, depression. From the senses: common – change in taste; rarely – blurred vision, amblyopia, loss of taste sensitivity, parosmiya. From the CCC: rarely – tachycardia, increased blood pressure, palpitations, chest pain, prolongation of the interval QT; rarely – lowering blood pressure, vasodilatation, part of the respiratory system: rarely – shortness of breath; rarely – asthma. On the part of the musculoskeletal system: rarely – arthralgia, myalgia; rarely – back pain, pain in the legs, arthritis, tendinopathy. From the urogenital system: rarely – vaginal candidiasis, vaginitis; rarely – pain in the abdomen, face edema, peripheral edema, renal failure. Allergic reactions: seldom – rash, itching; rarely – urticaria, anaphylactic shock. Local reactions: often – swelling, inflammation, pain at the injection site; rarely – phlebitis. Laboratory findings: rarely – leukopenia, increased prothrombin time, eosinophilia, thrombocytosis, increased amylase activity; rarely – reducing the concentration of thromboplastin decrease in prothrombin time, thrombocytopenia, anemia, hyperglycemia, hyperlipidemia, hyperuricemia, elevated LDH. Treatment: the appointment of activated charcoal – with an overdose of tablets (after an overdose of a solution for / infusion of activated carbon only 20% reduces the systemic exposure of the drug); symptomatic therapy.
Dosage and administration:
Orally or in form / infusion (slowly, over 60 min) – 400 mg 1 time per day. Swallow the tablet whole without chewing, regardless of the meal. The course of treatment during exacerbation of chronic bronchitis – 5 days, community-acquired pneumonia – 10 days, acute sinusitis, infections of the skin and soft tissues – 7 days. Do not need to change the dosage in elderly patients with liver (Group A, B on the scale of Child-Pyuga) and / or renal (including with CC less than 30 ml / min / 1.73 m) failure. Generic Avelox¬†(Moxifloxacin) you can buy Generic Avelox¬† through the Internet, it will cost you cheap (Discount card Generic Avelox¬†).
During therapy with fluoroquinolones can develop inflammation and tendon rupture, particularly in elderly patients and in patients receiving corticosteroids in parallel. At the first sign of pain or inflammation of the tendons, patients should discontinue treatment and immobilization of the affected limb. There is a direct correlation between the increase in the concentration of moxifloxacin and an increase in the interval QT (risk of ventricular arrhythmias, including torsades de pointes). As a result, should not exceed the recommended dose (400 mg) and soon infusion (at least 60 minutes). In the case of severe diarrhea during treatment with the drug should be discontinued.
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