The Latin name of the substance Paracetamol
Paracetamolum (genus. Paracetamoli)
N- (4-hydroxyphenyl) acetamide
Therapeutic agents Paracetamol
The nosological classification (ICD-10)
M25.5 Pain in the joints
Unspecified N94.6 Dysmenorrhea
R50 Fever of unknown origin
R52.2 Other constant pain
Mode of action – analgesic, antipyretic.
It inhibits PG synthesis and reduces the excitability of the hypothalamic thermoregulatory center. Rapidly absorbed from the gastrointestinal tract, binds to plasma proteins. T1 / 2 1-4 h plasma. Metabolized in the liver to form paracetamol glucuronide and sulfate. Report the news mostly in the form of conjugation products, less than 5% is excreted unchanged.
Application of the substance Paracetamol
mild to moderate intensity pain (headache, toothache, migraine, back pain, arthralgia, myalgia, neuralgia, menalgiya), a feverish syndrome with colds.
Contraindications of Paracetamol
Hypersensitivity, the functions of the kidneys and liver, alcoholism, children’s age (up to 6 years).
Side effects of substance Paracetamol
Agranulocytosis, thrombocytopenia, anemia, renal colic, aseptic pyuria, interstitial glomerulonephritis, allergic reactions such as skin rash.
Interaction of Paracetamol
It increases the effect of indirect anticoagulants (coumarin derivatives), and the probability of hitting hepatotoxic drugs liver. Metoclopramide increases and cholestyramine reduces the absorption rate. Barbiturates reduce the antipyretic activity.
Symptoms: in the first 24 hours – pallor, nausea, vomiting and pain in the abdominal area; after 12-48 hours – damage to kidney and liver with the development of liver failure (encephalopathy, coma, death), cardiac arrhythmias and pancreatitis. possible liver damage when taking 10 grams or more (for adults).
Treatment: the appointment of methionine inside or / in the introduction of N-acetylcysteine.
Dosing and Administration
Inside and rectally, adults and children over 12 years 0.5-1 g to 4 times per day; the maximum daily dose – 4 g, a course of treatment – 5-7 days. Children 6-12 years – 240-480 mg, 1-6 years – 120-240 mg, from 3 months to 1 year – 24-120 mg up to 4 times a day for 3 days. Soluble tablets before taking dissolved in 1/2 cup of water.