Paracetamol: instruction, application, and the formula

The Latin name of the substance Paracetamol

Paracetamolum (genus. Paracetamoli)

Chemical name

N- (4-hydroxyphenyl) acetamide



Therapeutic agents Paracetamol




The nosological classification (ICD-10)

M15-M19 Arthrosis

M25.5 Pain in the joints

M54.3 Sciatica

M79.1 Myalgia

Unspecified N94.6 Dysmenorrhea

R50 Fever of unknown origin

R51 Headache

R52.2 Other constant pain


Mode of action – analgesic, antipyretic.

It inhibits PG synthesis and reduces the excitability of the hypothalamic thermoregulatory center. Rapidly absorbed from the gastrointestinal tract, binds to plasma proteins. T1 / 2 1-4 h plasma. Metabolized in the liver to form paracetamol glucuronide and sulfate. Report the news mostly in the form of conjugation products, less than 5% is excreted unchanged.

Application of the substance Paracetamol

mild to moderate intensity pain (headache, toothache, migraine, back pain, arthralgia, myalgia, neuralgia, menalgiya), a feverish syndrome with colds.

Contraindications of Paracetamol


Hypersensitivity, the functions of the kidneys and liver, alcoholism, children’s age (up to 6 years).

Side effects of substance Paracetamol

Agranulocytosis, thrombocytopenia, anemia, renal colic, aseptic pyuria, interstitial glomerulonephritis, allergic reactions such as skin rash.

Interaction of Paracetamol


It increases the effect of indirect anticoagulants (coumarin derivatives), and the probability of hitting hepatotoxic drugs liver. Metoclopramide increases and cholestyramine reduces the absorption rate. Barbiturates reduce the antipyretic activity.


Symptoms: in the first 24 hours – pallor, nausea, vomiting and pain in the abdominal area; after 12-48 hours – damage to kidney and liver with the development of liver failure (encephalopathy, coma, death), cardiac arrhythmias and pancreatitis. possible liver damage when taking 10 grams or more (for adults).

Treatment: the appointment of methionine inside or / in the introduction of N-acetylcysteine.

Dosing and Administration

Inside and rectally, adults and children over 12 years 0.5-1 g to 4 times per day; the maximum daily dose – 4 g, a course of treatment – 5-7 days. Children 6-12 years – 240-480 mg, 1-6 years – 120-240 mg, from 3 months to 1 year – 24-120 mg up to 4 times a day for 3 days. Soluble tablets before taking dissolved in 1/2 cup of water.