Gyne-lotrimin (Clotrimazole)

Drug Information: Indications, Side Effects, Warnings

Category:  Women’s Health, Antifungals

Generic Gyne-Lotrimin is used to treat yeast (fungus) infections of the vagina.Gyne-lotrimin

Pharmacological groups: antifungals

Other synthetic antibacterials

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Nosological classification (ICD-10):

A59 Trichomoniasis
B37 Candidiasis
N76 Other inflammatory diseases of the vagina and vulva

Structure and Composition:

1 vaginal tablet contains 100 mg of clotrimazole; Blister of 6 pcs., complete with applicator.

1 g of a vaginal cream — 10 mg; in tubes of 50 g

Pharmacological action:

Pharmacological action — a broad spectrum antifungal, trihomonatsidnoe, antiprotozoal, antifungal, anti-fungal, anti-bacterial.

Causes changes in the walls of the fungus, inhibits the synthesis of sterols bacteria, trichomonads and leads to their death.

Indications of the drug:

Vulvovaginal candidiasis, Trichomonas vaginitis.

Fungal skin and mucous membranes: ringworm, tinea, trichophytosis, athlete, microsporia, candidiasis, a fungal interdigital erosion, fungal paronychia; mycoses complicated by secondary pyoderma; pityriasis versicolor, erythrasma; thrush; candidal vulvitis, vulvovaginitis, balanitis, trichomoniasis; for the rehabilitation of the birth canal before delivery.

Contraindications:

Hypersensitivity to clotrimazole.

Pregnancy and breast-feeding:

Not contraindicated in II and III trimester of pregnancy (data on the use in the I-trimester absent).

Side effects:

Vaginal irritation, burning sensation, skin rash, erythema, cramping abdominal pain, frequent urination, intercurrent cystitis, as well as burning and irritation of the genital organs of a partner.

Dosage and administration:

Intravaginally (tablets should be entered as far as possible). 1 table. per day for 6 days or Table 2. 3 consecutive days.

Vaginal cream, the recommended dose — full applicator once (preferably at bedtime) daily for 6-14 days.

Precautions:

Not recommended for use during menstruation. To prevent re-infection should be treated at the same time sexual partner (cream).

How it works:

— Violates the synthesis of ergosterol (the main structural component of the cell membrane of fungi)
— Changes the permeability of the membrane of the fungus
— Promotes the release of cells potassium intracellular phosphorus compounds
— Facilitates the disintegration of cellular nucleic acids.
— Inhibits the synthesis of triglycerides and phospholipids.
— Reduces activity of oxidative enzymes and peroxidase
— The intracellular concentration of hydrogen peroxide is increased to toxic levels. This contributes to the destruction of cellular organelles, leading to cell necrosis.
— Depending on the concentration, exhibits fungicidal or fungistatic effect.
— Inhibits the transformation of Candida albicans blastospores into invasive mycelial form.

Interaction:
Reduces the activity of (relative) polyene antibiotics (amphotericin B, nystatin, natamycin).

How to apply?

Topically with urogenital infections:

When candidiasis or balanitis vulvitis: used 2-3 times per day for 1-2 weeks.

For the treatment of trichomoniasis vaginitis in adults and adolescents: Vaginal tablet (500 mg dose or 200 mg for three days or 6-7 days, 100 mg, 1 times a day, in the evening). You can use cream (full applicator), which is introduced as deeply as possible into the vagina 1 time a day (at night).

For the preparation of the birth canal is recommended single administration of the tablet.

 

 

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