Alesse (Levonorgestrel Bp + Ethinylestradiol Bp)

Drug Information: Indications, Side Effects, Warnings

Category: Womens Health

Generic Alesse is used for preventing pregnancy.Alesse ordering

Brand(s): Ovral L

Manufacturer: Wyeth


Estrogens, progestins; antagonists, and their homologs in combinations

How it works:
Contraceptive estrogen-progestin combination drug. If ingestion it inhibits the secretion of pituitary gonadotropins. The contraceptive effect is due to several mechanisms.

Estrogenic component is ethinyl estradiol.

The drug inhibits the maturation and release ready to fertilize an egg (ovulation).

The contraceptive effect is enhanced by ethinylestradiol.

If ingestion, active substances rapidly and completely absorbed from the gastrointestinal tract.


  • Contraception, functional menstrual disorders(includingdysmenorrheawithoutorganic cause, dysfunctionalmetrorrhagia, pre-menstrualsyndrome).


— Hypersensitivity, hepatic failure, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), liver tumors (hemangioma, liver cancer).

-Malignant tumors (especially cancers of breast or endometrial cancer).

-The presence or indication of a history of severe cardiovascular and cerebrovascular disease, thromboembolism, and predisposition to them (ischemic or hemorrhagic stroke, common atherosclerosis, myocarditis, decompensated chronic heart failure, valvular heart disease, severe hypertension). Diabetes mellitus is a severe course (accompanied by retinopathy and microangiopathy).

-Sickle cell anemia, chronic hemolytic anemia, vaginal bleeding of unknown etiology, migraine.

-Otosclerosis; hydatidiform mole, otosclerosis with hearing loss, idiopathic jaundice or itching — during a previous pregnancy.

-Congenital hyperlipidemia, age over 40 years.

Under the supervision of a physician:

-Diseases of the liver and gall bladder, epilepsy, depression, ulcerative colitis, fibroids, breast, tuberculosis, kidney disease, adolescence (without regular ovulatory cycles).


Inside, in the 1 tablet 1 per day from day 1 or 5 of the menstrual cycle (depending on the type of preparation: monophasic, 2- or 3-phase) for 21 days. Then is follows a 7-day break.

Woman taking pills, not liquid, squeezed a small amount of liquid. While taking the pill does not matter.

To hormone concentrations in plasma were similar; the interval between doses tablets should not exceed 36 hours.

Side effects:

Nausea, vomiting, headache, breast tenderness, weight gain, loss of libido and mood, deepening of voice, appearance of intermenstrual bleeding, in some cases — swelling of the eyelids, conjunctivitis, blurred vision, discomfort while wearing contact lenses (these effects are temporary character and disappear after discontinuation of destination without any therapy).

Occasionally there may be chloasma, hearing loss, generalized pruritus, jaundice, leg cramps, increased frequency of seizures.

Rarely marked hypertriglyceridemia, hyperglycemia, impaired glucose tolerance, increased blood pressure, thrombosis and venous thromboembolism, skin rashes, changes in the nature of the vaginal secretions, vaginal candidiasis, fatigue, diarrhea.

Fertility recovers quickly, within 1-3 menstrual cycles after stopping the pill.

Before the start of contraception and every 6 months is recommended to general medical and gynecological examination (including the study of mammary glands, liver function, blood pressure control and the concentration of cholesterol in the blood, urine).

Smoking women taking hormonal contraceptive drugs have an increased risk of cardiovascular disease with serious consequences (myocardial infarction, stroke). The risk increases with age.

Contraceptive effect is reduced by vomiting and diarrhea.

Treatment must be stopped immediately if pregnancy occurs.

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