Drug Information: Indications, Side Effects, Warnings
Generic NoroxinÂ (Norfloxacin)
Category:Â Urinary Tract,Â Antibiotics
Description of the active substance:
The selling Generic NoroxinÂ (Norfloxacin) is by prescription.
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The antimicrobial agent of the fluoroquinolone group. Has a bactericidal effect by inhibiting DNA gyrase supercoiling and thus provides Bacterial DNA stability, leading to destabilization of the DNA chain, and death of the bacteria. Has a broad spectrum of antibacterial action. Sensitive: Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Citrobacter spp., Enterobacter spp.,Proteus spp., Salmonella spp., Vibrio parahaemolyticus, Chlamydia spp., Legionella spp. Different sensitivity to the drug have: Enterococcus faecalis, Streptococcus spp., Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter, Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, Mycobacterium fortuitum. Insensitive: Ureaplasma urealyticum, Nocardia asteroides, anaerobic bacteria (such as Bacteroides spp., Peptococcus spp., Peptostreptococcus spp., Eubacter spp., Fusobacterium spp., Clostridium difficile), Treponema pallidum. Duration of effect — about 12 hours.
Inside — bacterial urinary tract infection (pyelonephritis, cystitis, urethritis), genitals (prostatitis, cervicitis, endometritis), gastrointestinal tract (salmonellosis, shigellosis), uncomplicated gonorrhea. Prevention of infections in patients with granulocytopenia, travelers’ diarrhea. Locally — otitis externa, acute otitis average, chronic otitis media; prevention of infectious complications after surgical intervention on the organs of hearing; conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, Blepharoconjunctivitis, meybomit (barley), dacryocystitis; prophylaxis of eye infections after removal of foreign bodies from the cornea or conjunctiva after injury by chemical means before and after surgical operations on eyes.
Hypersensitivity, pregnancy, lactation, childhood and adolescence (18 years), lack of glucose-6-fosfatdegidrogenazy.With caution. Cerebral atherosclerosis, stroke, epilepsy, epileptic syndrome, renal / hepatic failure.
From the digestive system: loss of appetite, nausea, vomiting, abdominal pain, diarrhea. Urinary system: crystalluria, glomerulonephritis, dysuria, urethral bleeding. From the nervous system: headache, dizziness, fainting, insomnia, hallucinations. From the CCC: tachycardia, arrhythmias, lowering blood pressure. Allergic reactions: itching, swelling, malignant exudative erythema multiforme (Stevens-Johnson syndrome). From the senses (when applied topically): blurred vision, burning and pain in the eye, conjunctival hyperemia, photophobia. On the part of the musculoskeletal system: arthralgia, tendonitis, tendon rupture. From the side of hematopoiesis: leukopenia, eosinophilia, decreased hematocrit. Other: candidiasis. Symptoms (3 g for 45 min): dizziness, nausea, vomiting, drowsiness, «cold» sweat. Treatment: gastric lavage, adequate hydration therapy with forced diuresis. Requires inspection and observation in a hospital for a few days. No specific antidote.
Dosage and administration:
Inside: urinary tract infections — 400 mg 2 times a day for 7-10 days; with uncomplicated cystitis — 3-7 days; with chronic recurrent urinary tract infection — up to 12 weeks. Acute bacterial gastroenteritis — 5 days; in acute gonococcal urethritis, pharyngitis, proctitis, cervicitis — single 800 mg; typhoid fever — 400 mg three times a day for 14 days. To prevent sepsis — 400 mg 2 times a day; for the prevention of bacterial gastroenteritis — 400 mg / day. Patients with impaired renal function in spacecraft more than 20 ml / min correct dosing regimen is required. When QA below 20 ml / min (or serum creatinine level above 5 mg / 100 ml), and patients undergoing hemodialysis half the therapeutic dose administered 2 times a day, or one full dose once a day. Generic NoroxinÂ (Norfloxacin) you can buy through the Internet, it will cost you cheap. You can buy cheap Generic NoroxinÂ using coupons. Discount can reach up to 80%.
During treatment, patients should receive plenty of fluids (under the control of diuresis). During therapy may increase the prothrombin index (during surgery should monitor the status of the blood coagulation system). During treatment should avoid exposure to direct sunlight. Be careful when driving and other lesson. Potentially hazardous activities that require high concentration and speed of psychomotor reactions (especially while use of ethanol).
Decreases theophylline clearance by 25%, so while the application should reduce the dose of theophylline. Increasing the concentration of indirect anticoagulants, cyclosporine (each) in serum. Reduces the effect of nitrofurans. Simultaneous treatment with antacids containing aluminum or magnesium hydroxide, as well as drugs that contain Fe, Zn2 +, sucralfate reduces the absorption of norfloxacin (the interval between their appointment must be at least 4 hours). The simultaneous use of drugs that reduce epileptic threshold may lead to the development of epileptiform seizures. Simultaneous administration of norfloxacin with drugs that have the potential to reduce blood pressure, can cause a sharp decrease.
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