Drug Information: Indications, Side Effects, Warnings
Category:Â Urinary Tract
Generic Detrol is used for treating overactive bladder with symptoms of urinary frequency, urgency, and leakage.
Basic ingredient: Tolterodine
Therapeutic agents Tolterodine:
Nosological classification (ICD-10):
N31.1 Reflex bladder, not elsewhere classified
Characteristics of substance Tolterodine:
Tolterodine tartrate is a white crystalline powder. Size pKa — 9,87; solubility in water — 12 mg / ml; soluble in methanol, slightly soluble in ethanol, practically insoluble in toluene. Octanol / water at pH 7,3 is equal to 1.83.
Pharmacological action — antispasmodic.
Carcinogenicity, mutagenicity, effects on fertility:
Increased risk of cancer is not detected
Overactive Bladder, manifested by frequent Urinary urgency or incontinence.
Hypersensitivity, urinary retention, untreatable myasthenia gravis, angle-closure glaucoma, severe ulcerative colitis, megacolon.
A significant outflow tract obstruction of urine with the risk of urinary retention, gastrointestinal obstructive lesion (eg pyloric stenosis), kidney or liver failure, neuropathy, irreducible hernia, children’s age (safety and efficacy in children are not identified).
From the nervous system and sense organs: visual impairment (including breach of accommodation) — 4.7%, dizziness — 8.6%, headache — 11%, xerophthalmia — 3.8%, drowsiness — 3% fatigue — 6.8%.
Cardio-vascular system: arterial hypertension (vertigo) — 1.5%.
From the digestive tract: dry mouth — 39.5%, dyspepsia — 5.9%, nausea — 4.2%, constipation — 6.5% or diarrhea — 4%, abdominal pain — 7.6%, flatulence — 1.3%.
With the genitourinary system: urinary tract infection (difficulty, painful urination, urgency, Pyuria, hematuria) — 5.5%, dysuria — 2.5%.
Other: flu-like symptoms (including arthralgia) — 4.4%; allergic reactions — <1%. When receiving in the form of tablets: dry skin, bronchitis, weight gain — 1.10%, chest pain — 3.4%. When taken in the form of sustained-release capsules: sinusitis — 1-10%.
Symptoms: hallucinations, severe agitation, convulsions, respiratory failure, tachycardia, mydriasis, accommodation paresis, urinary retention, tenesmus.
Treatment: gastric lavage, activated charcoal, symptomatic therapy. When urinary retention — bladder catheterization. With strong central anticholinergic effects — physostigmine, in convulsions or an excited expression shown benzodiazepines (diazepam, lorazepam); under which developed respiratory failure — ventilator. Necessary to carry out ECG monitoring in connection with a possible extension of the interval QT. Tachycardia — beta-blockers. When mydriasis — with pilocarpine eye drops and / or transfer of the patient in a dark room.
Inside, 2 mg 2 times a day.
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