Grifulvin (Griseofulvin). Grifulvin v order now

Drug Information: Indications, Side Effects, Warnings

Category:  Skin Care, Antifungals

Generic Grifulvin is Antifungals. It is used for treating fungal infections of the scalp, body, foot (athlete’s foot), nails, thigh (jock itch), or hair follicles (barber’s itch).

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Therapeutic agents:

antifungals

Nosological classification (ICD-10)
B35.0 Mycosis beard and head
B35.1 Mycosis nail
B35.6 Athlete groin
B35.9 Dermatophytosis unspecified
B36.9 Superficial mycosis, unspecified

Characteristics of matter:

Antifungal agent. Antibiotic produced by mold fungi Penicillium nigricans (griseofulvum). White or white with a yellowish tinge naimelchayshy crystalline powder with low specific (mushroom) odor. Practically is insoluble in water and petroleum ether, slightly soluble in ethanol, methanol, acetone, benzene, ethyl acetate, acetic acid. Solubility in dimethylformamide at 25 ° C: 12-14 g / 100 ml. Stable at high temperatures, including autoclaving. The molecular weight is of 352.77.

Pharmacology:

Pharmacological action — antifungal, fungistatic.

Fungistatic action is due to the effect on microtubule proteins fungal cells. As a result, there is:
— Mitotic spindle-shaped gap structures
— Stop mitotic cell division in metaphase fungus
— Inhibits protein synthesis
— Adversely affects the formation of the cell wall chitin-containing fungi in.

The drug is active against mycetomas, including Trichophyton (Trichophyton rubrum, Trichophyton tonsurans, Trichophyton mentagrophytes, Trichophyton interdigitalis, Trichophyton verrucosum, Trichophyton sulphureum, Trichophyton menginii, Trichophyton gallinae, Trichophyton schoenleini, Trichophyton crateriforme), Microsporum (Microsporum audouinii, Microsporum canis, Microsporum gypseum ), Epidermophyton (Epidermophyton floccosum). Fungistatic concentration (for most types of fungi) is 0.5-3 mg / ml. Yeast-like fungi (genus Candida) and molds resistant to griseofulvin. The drug has no antibacterial activity.

Indications for use:

Use the following diseases: Mycoses of the skin, scalp and nails: favus, trichophytosis, microsporia scalp. Good results in the treatment of microsporia smooth skin, beard and mustache ringworm, athlete’s smooth skin, inguinal tinea, onychomycosis.

Contraindications

Hypersensitivity, porphyria, systemic lupus erythematosus, lupus-like syndrome, systemic blood diseases, leukopenia, organic liver and kidney disease, hepatocellular failure, malignant neoplasms.

Restrictions apply to:

Children under 2 years of age (efficacy and safety have not been identified).

Pregnancy and breast-feeding:

There is evidence of teratogenic and embryotoxic effects of griseofulvin in animals (for oral application in pregnant rats pups were born with multiple violations). The drug inhibits spermatogenesis in rats, although, studies in humans is unknown. Experiments on dogs showed that griseofulvin may cause adverse effects in the offspring.

Contraindicated in pregnancy (griseofulvin crosses the placenta). Since 1977, reported about two cases of conjoined twins birth in patients treated with griseofulvin in the I trimester of pregnancy. If a pregnancy occurring during therapy with griseofulvin, you must inform the patient of the potential risk to the fetus.

The use of breast-feeding is not recommended (not known whether griseofulvin passes into breast milk). Adequate data are not available.

Side effects:

From the digestive tract: Common: nausea, vomiting, dry mouth, diarrhea, abdominal pain, oral candidiasis. Sometimes: elevated liver enzymes, jaundice, hepatitis.

From the nervous system and sense organs are: headache, dizziness, excessive fatigue or weakness, insomnia, peripheral neuropathy, paresthesia of the extremities. Patients complain of poor coordination, confusion, disorientation, confusion, depression, disturbance of taste sensitivity.

Cardio-vascular system and blood (blood, hemostasis): granulocytopenia, agranulocytosis, leukopenia.

Allergic reactions: often occur: rash, pruritus, urticaria, angioedema, photosensitivity, lupus syndrome, erythema multiforme exudative, topical epidermal necrolysis (Lyell’s syndrome). Consult your doctor if during the treatment you notice side effects.

 

 

 

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