Fosamax (Alendronate), Does fosamax cause weight gain

Drug Information: Indications, Side Effects, Warnings

Category:  Osteoporosis

Generic Fosamax is used for treating and preventing osteoporosis in certain patients.

Clinical-pharmacological group:

An inhibitor of bone resorption in osteoporosischeap Fosamax

Composition, structure and packing:

Tablets are white or almost white, biconvex, without risks.

Main ingredient: alendronate sodium monohydrate

Pharmacological action:

An inhibitor of bone resorption. The drug belongs to the group aminobisphosphonates — synthetic analogs of pyrophosphate that binds to hydroxyapatite, which is part of the bone. The drug increases bone mineral density of the spine and other bones of the skeleton. The mechanism associated with the inhibition of osteoclast function. It is Promotes formation of bone tissue with normal histology.

Pharmacokinetics:

Absorption:

The ingestion fasting (5 to 70 mg), the bioavailability of alendronate in women was 0.64% for men — 0.6%.

The bioavailability of alendronate is reduced by 40% in the fasting state for 1-1.5 hours before breakfast.
After drinking coffee and orange juice, bioavailability is reduced by approximately 60%.

Distribution:

Alendronic acid binding to plasma proteins is approximately 78%. The drug is distributed in soft tissues and then rapidly redistributed to bone, where it is fixing or excreted in the urine.

The concentration of drug in plasma after oral administration at therapeutic dose is <5 ng / mL.

Metabolism:

Not biotransformation.

Excretion:

Excreted unchanged. The process of elimination is characterized by a rapid decrease in the concentration of alendronate in plasma and very slow release from the bones.

 

Dosage:

To ensure proper absorption of the drug and reduce the risk of adverse reactions, the patient should strictly comply with the doctor’s recommendation for use and dosage.

 

A tablet must be taken as a whole, with a glass of water for at least 30 minutes before the first meal, beverage or other medicaments.

The drug is washed down with plain water. Other beverages (including mineral water), food and certain medications may reduce the bioavailability of alendronate. Tablets should not be chewed or dissolve.

 

Overdose:

Symptoms: hypocalcemia, hypophosphatemia, diarrhea, heartburn, esophagitis, erosive and ulcerative lesions of the gastrointestinal tract.

Treatment: Milk or an antacid binds alendronate. When there is the risk of vomiting irritation of the esophagus. Do not induce vomiting. The patient should be in the upright position.

Pregnancy and lactation:

The drug is contraindicated in pregnancy and lactation (breastfeeding).

 

Side effects:

From the digestive system: often — pain in the stomach, indigestion, acid regurgitation, nausea, constipation, diarrhea, dysphagia, flatulence, gastritis, gastric ulcer, ulceration of the mucous membrane of the esophagus; rarely — nausea, vomiting, gastritis, esophagitis, esophageal erosion, melena; rarely — esophageal stricture, ulceration of the oropharynx, perforation, ulcers, bleeding in the upper gastrointestinal tract, although a causal relationship has not been established.

On the part of the musculoskeletal system: often — bone, muscle and joint pain, muscle cramps; rarely — osteonecrosis. There are reports of osteonecrosis of the jaw in patients taking bisphosphonates. Most of the communication relates to cancer patients, but such cases have also been reported in patients who were on therapy for osteoporosis.

From the nervous system: often — headache.

Dermatological reactions: seldom — rash, pruritus, erythema; rarely — rash with sensitivity; in some cases — severe skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis.

Allergic reactions: rarely — hypersensitivity reactions including urticaria and angioedema.

On the part of the organ of vision: rarely — uveitis, scleritis, episcleritis.

On the part of the body as a whole: rarely — transient symptoms similar to symptoms in the acute phase of the disease (myalgia, malaise and rarely fever), usually at the beginning of treatment; Symptomatic hypocalcemia, usually associated with predisposing conditions.

 

Indications for use:

— Treatment of postmenopausal osteoporosis;

— Osteoporosis caused by the use of corticosteroids.
Contraindications

— Hypocalcemia;

— Conditions leading to slower movement of food through the esophagus (including stricture or achalasia of the esophagus);

— The patient’s inability to stand or sit upright for at least 30 minutes;

— Renal failure, severe (creatinine clearance less than 35 mL / min);

— Severe disorders of mineral metabolism;

— Children’s age;

— Pregnancy;

— Lactation (breastfeeding);

— Hypersensitivity to the drug.

Use in patients under the supervision of a physician:
— in diseases of the gastrointestinal tract in the acute phase (dysphagia, esophagitis, gactrit, duodenitis, gastric ulcer and duodenal ulcer), hypovitaminosis D.

— In appointing the drug to patients with diseases of the gastrointestinal tract, such as dysphagia, esophagitis, gastritis, duodenitis, gastric ulcer and duodenal ulcer in the acute stage

— With a recent history (within the previous year), gastrointestinal diseases (peptic ulcer and duodenal ulcer, active gastrointestinal bleeding, surgery in the upper gastrointestinal tract other than pyloroplasty).

In renal impairment:

Is contraindicated in severe renal impairment (creatinine clearance less than 35 ml / min).

Application in childhood:

Contraindicated in children’s age.

Conditions of supply of pharmacies:

Drug prescription.

The drug is available over the counter or order online. You can buy Generic Fosamax (Alendronate) is cheaper if you use a coupon or discount cards.

 

Prices for 1 dose pack-4 tablets of generic alendronate 35-70mg

 

 

 

 

 

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