Actonel (Residronate)

 Drug Information: Indications, Side Effects, Warnings

Category: Osteoporosis

Generic Actonel is used for treating and preventing osteoporosis in certain patients.50 mg Actonel online

There are contraindications. Before taking consult your doctor.

Commercial names — Acitonal, Acrel, Actonel, Atelvia, Benet, Donaxib, Ductonar, Fossical, Gemfos, Maxtral, Optinate, Orafix, Osteonate, Retonel, Ribastamin, Ridron, Risebon, Risofos.

 

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Clinical-pharmacological group:

An inhibitor of bone resorption in osteoporosis.

Risedronic acid binds to hydroxyapatite at the cellular level and inhibits the function of osteoclasts and reduces bone resorption. Time to achieve maximum therapeutic effect is 3-6 months, the duration of therapeutic action — 12 months.

The drug is rapidly absorbed in the stomach.
Communication plasma proteins are 24%. The volume of distribution is 6.3 l / kg.

Approximately half of the absorbed dose is excreted by the kidneys within 24 hours.

Unabsorbed Risedronic acid is derived through the intestines in unchanged form.

Indications for use of the drug Generic Actonel (Residronate):

-treatment of established postmenopausal osteoporosis;

-treatment of osteoporosis in men at high the risk of a broken bone

A tablet is taken once a week in the same day of the week.

The tablet should be taken as a whole and not chewed, better standing and drink plain water (> 120 ml).

Side effects:

From the digestive system:

Common side effects: constipation, indigestion, nausea, abdominal pain, diarrhea.

Infrequent: gastritis, esophagitis, dysphagia, duodenitis, esophageal ulcer.

Rare: glossitis, esophageal stricture.

From the nervous system:

Frequent headache.

Rare: dizziness, asthenia, fatigue.

On the part of the musculoskeletal system:

Common: musculoskeletal pain.

Rare: leg cramps.

Very rare: osteonecrosis of the jaw (after tooth extraction or oral inflammation).

From the senses:

Uncommon: iritis (hyperemia of the sclera, eye pain).

Rare: amblyopia, blurred vision, dry mucous membranes of the eyes, ringing in the ears.

Other: infections (including urinary tract), a rise in blood pressure.

Other side effects:

-loss of hair;

-Allergic-type reactions: angioedema, urticaria;

-disorders of the skin: leukocytoclastic vasculitis, Stevens-Johnson syndrome and toxic epidermal necrolysis;

-anaphylactic reaction;

-severe hepatic impairment (in most reported cases, patients were also receiving other drugs that can cause liver damage);

-slight decrease in serum concentrations of calcium and phosphate.

Contraindications:

-hypersensitivity to the drug;

-hypocalcemia;

-severe renal impairment (creatine clearance less than 30 ml / min);

-pregnancy and breastfeeding (lactation);

-Children up to age 18;

Generic Actonel should not be used during pregnancy and lactation.
Treatment: active drinking milk, the use of antacids containing magnesium, calcium or aluminum. Sometimes there is a need for a gastric lavage.

Conditions of supply of pharmacies:

Drug prescription.

Conditions and terms:

The drug does not require any special storage conditions. It should be stored out of reach of children. Shelf life is 2 years.

 

 

 

 

 

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