Drug Information: Indications, Side Effects, Warnings
Category:Â Muscle Relaxants
Centrally acting, muscle relaxant agent [Drugs affecting neuromuscular transmission]
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Nosological classification (ICD-10)
G35 Multiple sclerosis
G93 Other disorders of brain
G95 Other diseases of spinal cord
R25.2 cramps and spasms
T09.3 Injury of spinal cord, level unspecified
Reduces intensity of muscle spasms and painful involuntary muscle spasms
- Reduces the motor automatism and clonic convulsions.
- Increased physical activity of patients
- Improving their ability to self-service,
- Facilitates rehabilitation therapy
With the weakening of the painful muscle spasms in patients:
- Increasing the amount of active movements,
- It avoids the formation and accelerated healing of pressure sores,
- Improves sleep patients —Â lioresal 10 mg prospecto.
- Also, the patient is: normalized bladder function that facilitates its insertion. The drug enhances the quality of life of patients.
The drug has a general dampening effect on the central nervous system, can cause sedation, drowsiness and inhibits the function of the respiratory and cardiovascular systems.
Severe chronic spasticity in lesions of the spinal (eg due to injury, multiple sclerosis), or the brain with the ineffectiveness or intolerance to treatment for oral muscle relaxants.
Hypersensitivity to baclofen or any other components of the drug;
Children age â‰¤4 years (effectiveness and safety of the drug in children younger than 4 years old have not been established).
CNS: often — drowsiness; often — sedation, dizziness / staggering, convulsions, headache, paresthesia, accommodation disturbances / blurred vision / double vision, dysarthria, confusion, fatigue, respiratory depression, insomnia, confusion / disorientation, anxiety / agitation, depression; sometimes — hypothermia, nystagmus, dysphagia, ataxia, impaired memory, suicidal thoughts and attempts, euphoria, dysphoria, hallucinations, paranoid reactions. Seizures and headache occur more often in patients with spasticity of cerebral origin than in patients with spasticity of spinal origin.
Since the cardiovascular system: often — hypotension; sometimes — hypertension, bradycardia, deep vein thrombosis, redness or paleness of skin (different location).
The respiratory system: often — shortness of breath, bradypnea pneumonia.
From the digestive system: often — nausea / vomiting, constipation, dry mouth, diarrhea, decreased appetite, increased salivation; sometimes — dehydration, ileus, taste disturbances. Nausea and vomiting are more frequent in patients with spasticity of cerebral origin than in patients with spasticity of spinal origin.
Dermatological reactions: often — hives / itching, swelling of the face / peripheral edema; sometimes — alopecia, profuse sweating.
With the genitourinary system: often — urinary incontinence, urinary retention, different sexual dysfunction. Urinary retention occurs more frequently in patients with spasticity of cerebral origin than in patients with spasticity of spinal origin.
From the musculoskeletal system: very often — muscle hypotonia; often — increased muscle tone.
Other: often — pain, fever / chills.
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