Seroquel: Instructions for use

Seroquel is an oral antipsychotic drug to treat major depressive disorder, schizophrenia and bipolar disorder.

Pharmacological group of Seroquel

antipsychotics

The nosological classification (ICD-10) of Seroquel

F20 Schizophrenia

Inorganic psychosis F29 Unspecified

F31 Bipolar affective disorder

Release form, composition and packing

The tablets covered with a film cover of pink color, round, biconcave, with chasing «SEROQUEL 25″ on one side.

1 tab.

Quetiapine fumarate 28.78 mg,

that corresponds to the content of quetiapine 25 mg

Excipients: povidone, dicalcium phosphate, microcrystalline cellulose, sodium carboxymethyl starch, lactose monohydrate, magnesium stearate.

shell composition: dye iron oxide red, iron oxide yellow colorant, titanium dioxide, hypromellose, macrogol 400.

10 pieces. — Blisters (6) — packs cardboard.

Tablets, film-coated yellow, round, biconvex, engraved with «SEROQUEL 100″ on one side.

1 tab.

Quetiapine fumarate 115.13 mg,

that corresponds to the content of quetiapine 100 mg

Excipients: povidone, dicalcium phosphate, microcrystalline cellulose, sodium carboxymethyl starch, lactose monohydrate, magnesium stearate.

Cover structure: iron oxide yellow dye, titanium dioxide, hypromellose, macrogol 400.

10 pieces. — Blisters (6) — packs cardboard.

Tablets, film-coated white, round, biconvex, engraved with «SEROQUEL 200″ on one side.

1 tab.

Quetiapine fumarate 230.26 mg,

that corresponds to the content of quetiapine 200 mg

Excipients: povidone, dicalcium phosphate, microcrystalline cellulose, sodium carboxymethyl starch, lactose monohydrate, magnesium stearate.

Cover structure: titanium dioxide, hypromellose, macrogol 400.

10 pieces. — Blisters (6) — packs cardboard.

Daily dose of four first therapeutic days is 50 mg, 100 mg (second day), 200 mg (third day), 300 mg (fourth day). Starting from the fourth day the dosage should be adjusted to the level of effective one (which can reach 750 mg daily). In patients with liver or kidney failure initial dose is 25 mg/day increased gradually by 25-50 mg till the effective dose is reached.

Daily dose of four first therapeutic days is 50 mg, 100 mg (second day), 200 mg (third day), 300 mg (fourth day). Starting from the fourth day the dosage should be adjusted to the level of effective one (which can reach 750 mg daily). In patients with liver or kidney failure initial dose is 25 mg/day increased gradually by 25-50 mg till the effective dose is reached.

Indications for use Seroquel

— Acute and chronic treatment of psychosis, including schizophrenia;

— The treatment of manic episodes of bipolar disorder in the structure;

— Treatment of depressive episodes of moderate to severe degree of weight in the structure of bipolar disorder (for 8 weeks).

Contraindications of Seroquel

— Concomitant use with inhibitors of cytochrome P450 (antifungal azole group, erythromycin, clarithromycin, nefazodone, protease inhibitors);

— Hypersensitivity to any component of the drug.

Side effects of Seroquel

From the central and peripheral nervous system: often — somnolence (17.5%), dizziness (10%); rarely — neuroleptic malignant syndrome (hyperthermia, altered mental status, muscular rigidity, vegetative-vascular disorders, increased CK); very rarely — seizures. With prolonged use of quetiapine potential exists for the development of tardive dyskinesia. If you have any symptoms of tardive dyskinesia is necessary to reduce the dose or discontinue further treatment with quetiapine.

From the digestive system: often — constipation (9%), dyspepsia (6%), dry mouth (7%); Increases in liver enzymes (ALT, AST, GGT) in the blood serum (6%), as well as increasing the concentration of cholesterol and triglycerides (during treatment with quetiapine, these changes tend to be reversible).

Since the cardiovascular system: often — orthostatic hypotension (dizziness accompanied by), tachycardia (7%), syncope; These side reactions are mainly found in the initial dose titration period.

Hematopoietic system: rarely — leukopenia and / or neutropenia. There were no cases of severe neutropenia or agranulocytosis in patients taking Seroquel. When using quetiapine in clinical practice leukopenia and / or neutropenia resolved after discontinuation of the drug. Possible risk factors for leucopenia and / or neutropenia include a reduction in the number of white blood cells before treatment, or available in the anamnesis on leukopenia and / or neutropenia caused by taking drugs.

From endocrine system: quetiapine therapy is associated with a slight dose-dependent decrease in thyroid hormone levels, particularly total T4 and free T4. The maximum decrease in total and free T4 was registered on the 2nd and 4th week of therapy with quetiapine, without further reducing the concentration of hormones during prolonged treatment. In the future, there was no evidence of clinically relevant changes in the concentration of thyroid-stimulating hormone. In almost all cases, the concentration of total and free T4 returned to baseline after discontinuation of quetiapine therapy regardless of the duration of treatment.

Allergic reactions: seldom — eosinophilia, allergic reactions, including angioedema.

Other: rarely — peripheral edema, mild asthenia, rhinitis, weight gain (especially in the first weeks of treatment); very rarely — priapism.