Drug Information: Indications, Side Effects, Warnings
Category: Â Mental Disorders, Anticonvulsants
Indications for use
The partial and generalized seizures, including tonic-clonic and associated with Lennox-Gastaut syndrome (adults and children), bipolar disorders in adults older than 18 years with predominantly depressive phases.
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Nosological classification (ICD-10):
F31 Bipolar affective disorder
G40.1 localized (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
G40.3 Generalized idiopathic epilepsy and epileptic syndromes
G40.6 grand mal seizures, unspecified [with small seizures [petit mal] or without]
Small seizures G40.7 [petit mal], unspecified, without grand mal seizures
Description pharmaceutical form
The dose of 5 mg: oblong, biconvex, one side of which is affixed by squeezing Â«GS CL2Â», on the other side — «5». May include the small blotches.
The dose of 25 mg: square with rounded corners, with a convex square and the number «25» on one side, the other side by extrusion affixed Â«GS CL5Â». May include the small blotches.
The dose of 100 mg: square with rounded corners, with a convex square and the number «100» on one side, the other side by extrusion affixed Â«GS CL7Â». May include the small blotches.
Mode of action — an anticonvulsant.
Blocks voltage-gated sodium channels to stabilize neuronal membranes and inhibits the release of glutamate, which plays a key role in causing seizures.
Precautions should be prescribed in patients with renal insufficiency.
Use in pregnancy
the risk of birth defects in the fetus while taking the drug during pregnancy.
Lamictal side effects when stopping
Skin and subcutaneous tissue: often — skin rash, mostly maculopapular nature; rarely — exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome).
Skin rash usually appears within the first 8 weeks from the start of the use of lamotrigine and passes with its abolition.
In rare cases can develop severe skin reactions, which in most cases disappear after drug withdrawal (some patients may remain scars), and are potentially life-threatening conditions such as Stevens-Johnson syndrome and Lyell.
On the part of the blood and lymphatic system: rarely — neutropenia, leukopenia, anemia, thrombocytopenia, pancytopenia, aplastic anemia, agranulocytosis.
Hematologic abnormalities may be associated and not associated with hypersensitivity syndrome and DIC syndrome.
Immune system: rarely — hypersensitivity syndrome with symptoms such as fever, lymphadenopathy, facial edema, hematologic abnormalities, liver damage, DIC syndrome, multiple organ failure.
The early signs of hypersensitivity (for example fever, lymphadenopathy) may occur even in the absence of skin rash. In this case, the patient should immediately stop taking the view and lamotrigine, if there is no other obvious causes of such symptoms.
Skin rashes are part of the syndrome, hypersensitivity, the severity of which may be different, in rare cases, until the development of multiple organ dysfunction syndrome and DIC.
CNS: often — irritability, anxiety, headache, fatigue, drowsiness, insomnia, vertigo, imbalance, tremors, nystagmus, ataxia.
Sometimes, — aggression.
Rarely — tics, hallucinations, confusion, agitation, impaired balance, movement disorders, extrapyramidal disorders, choreoathetosis, increased seizures.
From the side view: often — diplopia, blurred vision, conjunctivitis.
From the digestive system: often — dysfunction of the gastrointestinal tract, including nausea, vomiting and diarrhea; rarely — increased rates of liver function tests, hepatic dysfunction, hepatic failure.
From the musculoskeletal system: often — arthralgia, back pain; rarely — lupus-like syndrome.
Other: abrupt withdrawal of Lamictal, as well as other anti-epileptic drugs can cause increased frequency of seizures associated with the development of the syndrome.