Drug Information: Indications, Side Effects, Warnings
Category:Â Mental Disorders
Generic Anafranil Sustained-Release is used for treating obsessive-compulsive disorder (OCD).
Brand(s): Clonil SR / Clofranil
Manufacturer: Intas / Sun Pharmaceutical
Form and description:
Sustained-release tablets, coated pink kapsulovidnye, lenticular
The basic ingredient: clomipramine hydrochloride 75 mg
Other ingredients: calcium hydrogen phosphate dihydrate, polyacrylate dispersion 30%, calcium stearate, colloidal anhydrous silica, hydroxypropyl cellulose, talc, titanium dioxide, polyoxyl 40 hydrogenated castor oil, iron oxide red.
Clinic-pharmacological group: Antidepressant
Indications of use:
— Obsessive-compulsive syndromes;
— Chronic pain syndrome;
— Phobias and panic attacks;
— Cataplexy, narcolepsy companion.
— The treatment of depressive states with different symptoms: endogenous, reactive, neurotic, organic, masked, involutional forms of depression; depression in patients with schizophrenia and psychopathy; depressive syndromes that occur in old age due to chronic pain or chronic physical illness; depressive mood disorders reactive, neurotic or psychopathic nature.
Use in Children and Teens:
— Obsessive-compulsive syndromes;
— Nocturnal enuresis
In depression, obsessive-compulsive syndrome and phobias:
— the initial daily dose is 75 mg 1 time / day
Panic disorder, agoraphobia:
-starting dose is 10 mg / day.
When cataplexy accompanying narcolepsy:
-daily dose is 25-75 mg.
In chronic pain syndromes:
-the dose is adjusted individually.
CNS and peripheral nervous system:
-very often — drowsiness, fatigue, restlessness, increased appetite; often — confusion, disorientation, hallucinations (especially in elderly patients and in patients with Parkinson’s disease), anxiety, agitation, sleep disturbances, mania, hypomania, aggressiveness, memory impairment, depersonalization, increased depression, impaired concentration, insomnia, nightmares, yawning; sometimes — activation of psychotic symptoms.
Neurological status: very often — dizziness, tremor, headache, myoclonus; often — delirium, speech disorders, paresthesia, muscle weakness, increased muscle tone; sometimes — seizures, ataxia; very rarely — EEG changes, increased body temperature.
Effects due to anticholinergic activity: very often — dry mouth, increased sweating, constipation, accommodation disturbances, blurred vision («blurred vision»), voiding; often — flushing, mydriasis; very rarely — glaucoma, urinary retention.
Đˇcardiovascular system: often — sinus tachycardia, palpitations, orthostatic hypotension, clinically insignificant ECG changes (eg ST interval or tooth T) in patients without heart disease; sometimes — arrhythmias, increased blood pressure; very rarely — a violation of intracardiac conduction (eg, expansion of the complex QRS, lengthening the interval QT, change the interval PQ, Bundle Branch Block, torsades ventricular tachycardia / ventricular arrhythmias such as «pirouette» /), particularly in patients with hypokalemia).
From the digestive system: very often — nausea; often — vomiting, abdominal discomfort, diarrhea, anorexia, elevated transaminase levels; very rarely — hepatitis with jaundice or without it.
Dermatological reactions: often — allergic skin reactions (rash, urticaria), photosensitivity, pruritus; very rarely — edema (local or general), hair loss.
Endocrine system and metabolism: often — increased body weight, a violation of libido and potency; often — galactorrhea, breast enlargement; very rarely — a syndrome of inappropriate secretion of antidiuretic hormone.
Hypersensitivity reactions: very rarely — allergic alveolitis (pneumonitis).
Hematopoietic system: rarely — leukopenia, agranulocytosis, eosinophilia, thrombocytopenia, purpura.
The elderly are particularly susceptible to the action of Anafranil on the nervous system, the cardiovascular system, the effect of the drug on the mental status, as well as to the anticholinergic effects.
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