Anafranil (Clomipramine)

Drug Information: Indications, Side Effects, Warnings

Category: mental disorders, antidepressants

Mental Disorders, Antidepressants

Generic Anafranil is used for treating obsessive-compulsive disorder (OCD).cheap Anafranil canada

Brand(s): Clonil / Clofranil

Manufacturer: Intas / Sun Pharmaceutical

Composition, structure and packing:

Coated tablets light yellow sugar; round, biconvex.

Basic ingredient: clomipramine hydrochloride

Other ingredients: lactose, corn starch, colloidal anhydrous silica, stearic acid, talc, magnesium stearate, glycerol 85%, hydroxypropylmethylcellulose, vinylpyrrolidone / vinyl acetate, titanium dioxide, sucrose crystal, polyvinylpyrrolidone K30, disperse yellow 15093 ansted (yellow iron oxide (EES172) + 5% titanium dioxide (EES171) 95%), polyethylene glycol 8000 (macrogol 8000), microcrystalline cellulose.

Generic Anafranil effect on depressive symptoms in general, including especially in its typical symptoms such as psychomotor retardation, depressed mood and anxiety. The clinical effect is usually observed after 2-3 weeks of treatment.

Dosage:

Dose is picked individually, taking into account the patient’s condition.

Overdose:

Symptoms developing in overdose Anafranil are similar to those described in overdose other tricyclic antidepressants. The main complications are violations of the activity of the heart and neurological disorders.

 

CNS: drowsiness, stupor, coma, ataxia, restlessness, agitation, increased reflexes, muscle rigidity, horeoatetoidnye movements, convulsions. In addition, there may be manifestations of serotonin syndrome (fever, myoclonus, delirium, coma).

Cardio-vascular system: marked reduction of blood pressure, tachycardia, prolongation of the interval QTc, arrhythmia (including ventricular arrhythmias such as «pirouette»), violation of intracardiac conduction, shock, heart failure; in very rare cases — cardiac arrest.

 

Other: possible respiratory depression, cyanosis, vomiting, fever, mydriasis, sweating, oliguria or anuria.

Treatment: symptomatic. If the patient is conscious, it should be as soon as possible to gastric lavage or induce vomiting.

 

Pregnancy and lactation

Experience of using Anafranil in pregnancy is limited. The drug causes abnormalities in the developing fetus. The doctor should not prescribe this drug during pregnancy.

 

Side effects:
CNS and peripheral nervous system. Mental status: very often — drowsiness, fatigue, restlessness, increased appetite; often — confusion, disorientation, hallucinations (especially in elderly patients and in patients with Parkinson’s disease), anxiety, agitation, sleep disturbances, mania, hypomania, aggressiveness, memory impairment, depersonalization, increased depression, impaired concentration, insomnia, nightmares, yawning; sometimes — activation of psychotic symptoms. Neurological status: very often — dizziness, tremor, headache, myoclonus; often — delirium, speech disorders, paresthesia, muscle weakness, increased muscle tone; sometimes — seizures, ataxia; very rarely — EEG changes, increased body temperature.

 

Cardio-vascular system: often — sinus tachycardia, palpitations, orthostatic hypotension, clinically insignificant changes in the ECG (eg, ST interval or tooth T) in patients without heart disease; sometimes — arrhythmias, increased blood pressure; very rarely — a violation of intracardiac conduction (eg, expansion of the complex QRS, lengthening the interval QT, change the interval PQ, Bundle Branch Block, torsades ventricular tachycardia / ventricular arrhythmias such as «pirouette» /), particularly in patients with hypokalemia).

 

From the digestive system: very often — nausea; often — vomiting, abdominal discomfort, diarrhea, anorexia, elevated transaminase levels; very rarely — hepatitis with jaundice or without it.

Dermatological reactions: often — allergic skin reactions (rash, urticaria), photosensitivity, pruritus; very rarely — edema (local or general), hair loss.

Part of the endocrine system and metabolism: often — increased body weight, disturbances of libido and potency; often — galactorrhea, breast enlargement; very rarely — a syndrome of inappropriate secretion of antidiuretic hormone.

 

Hematopoietic system: rarely — leukopenia, agranulocytosis, eosinophilia, thrombocytopenia, purpura.

From the senses: common — taste disturbance, tinnitus.

Other: after the sudden cancellation or rapid dose reduction Anafranil often have the following symptoms: nausea, vomiting, abdominal pain, diarrhea, insomnia, headache, irritability, anxiety.

 

Indications for use:

Adult patients:

— The treatment of depressive states of different etiology that occur with different symptoms: endogenous, reactive, neurotic, organic, masked, involutional forms of depression; depression in patients with schizophrenia and psychopathy; depressive syndromes that occur in old age; depressive mood disorders reactive, neurotic or psychopathic nature;

— Obsessive-compulsive syndromes;

— Chronic pain syndrome;

— Phobias and panic attacks;

— Cataplexy, narcolepsy companion.

 

Children and adolescents:

— Obsessive-compulsive syndromes;

— Nocturnal enuresis (only in patients over the age of 5 years and subject to the exclusion of organic causes of disease).

 

Contraindications:

— Hypersensitivity to clomipramine and other components of the drug, cross-hypersensitivity to tricyclic antidepressants from the group dibenzazepine;

— The simultaneous use of MAO inhibitors; during at least 14 days before and after their use;

— Simultaneous application of selective inhibitors of MAO-A reversible action (such as moclobemide);

— Recent myocardial infarction;

— Congenital syndrome QTc QT.

Do not use the drug during pregnancy and breastfeeding.

The drug is not recommended for use in children under the age of 5 years.

 

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