Drug Information: Indications, Side Effects, Warnings
Category: Mental Disorders
Composition, structure and packing:
Tablets blue, rectangular with rounded edges
Main ingredient: aripiprazole
Other ingredients: lactose monohydrate, microcrystalline cellulose, corn starch, giproloza, magnesium stearate, aluminum blue lacquer.
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Treatment of overdose:
Monitoring vital signs, ECG, supportive therapy, airway, oxygenation, effective ventilation, activated charcoal, symptomatic treatment, careful medical supervision until the disappearance of all symptoms.
Symptoms of overdose:
Lethargy, increased blood pressure, somnolence, tachycardia, loss of consciousness.
Side effects of medications:
often — orthostatic hypotension, tachycardia; sometimes — bradycardia, palpitations, myocardial infarction, lengthening the interval QT, cardiac arrest, hemorrhage, atrial fibrillation, heart failure, AV-block, myocardial ischemia, deep vein thrombosis, phlebitis, beats; rarely — vasovagal syndrome, atrial flutter, thrombophlebitis, intracranial hemorrhage, cerebral ischemia; very rare — fainting, increased blood pressure.
From the digestive system:
very often — nausea, loss of appetite; often — increased appetite (for the treatment of depression in combination with antidepressants), dyspepsia, vomiting, constipation, hypersecretion of saliva, dry mouth, heaviness in the abdomen, diarrhea; sometimes — gastroenteritis, difficulty swallowing, flatulence, gastritis, dental caries, gingivitis, hemorrhoids, gastroesophageal reflux disease, gastrointestinal hemorrhage, periodontal abscess, swelling of the tongue, faecal incontinence, colitis, rectal hemorrhage, stomatitis, ulceration of the oral mucosa, cholecystitis, fekaloma, candidiasis of the oral mucosa, belching, stomach ulcers; rarely — esophagitis, bleeding gums, inflammation of the tongue, hematemesis, intestinal bleeding, duodenal ulcer, cheilitis, enlargement of the liver, intestinal perforation; very rarely — increased activity of ALT, AST and ALP, hepatitis, jaundice, pancreatitis, dysphagia.
often — arthralgia, muscle rigidity; sometimes — myasthenia gravis, arthritis, arthrosis, muscle weakness, muscle spasms, bursitis; very rarely — increased CPK, rhabdomyolysis, tendonitis, tenobursit, myalgia.
Central nervous system and peripheral nervous system:
very often — insomnia, headache, akathisia (in patients with bipolar disorder); often — drowsiness, dizziness, tremor, extrapyramidal syndrome, agitation, depression, nervousness, hostility, suicidal thoughts, manic thoughts, confusion, resistance to the implementation of passive movements syndrome (gear), lethargy, reduced concentration, sedative effect; sometimes — dystonia, muscle twitching, paresthesia, tremor of limbs, impotence, bradykinesia, decreased / increased libido, panic reactions, lethargy, memory loss, stupor, amnesia, stroke, hyperactivity, depersonalization, dyskinesia, a syndrome of «restless legs», myoclonus, depressed mood, increased reflexes, slowing of mental function, increased sensitivity to stimuli, violation of oculomotor reaction; rarely — delirium, euphoria, bukkoglossalny syndrome, akinesia, depression of consciousness until he lost consciousness, decreased reflexes, obsessive thoughts, CSN; very rarely — a speech disorder, seizures.
often — dry skin, itching, skin ulceration; sometimes — acne, vezikulobuleznaya (bubble), eczema, alopecia, psoriasis, seborrhea; rarely — makulo-papular rash, exfoliative dermatitis, hyperhidrosis.
Rarely — anaphylaxis, angioedema, pruritus, urticaria, laryngospasm.
Storage conditions and shelf:
The drug should be Keep out of reach of children, dry place at a temperature of 15 Â° to 30 Â° C. Shelf life — 3 years.
Indications for use:
— Mental Disorders
— Schizophrenia: acute attacks and supportive therapy;
— Bipolar I disorder: manic episodes and maintenance treatment in patients with bipolar I disorder
— As an adjunct to therapy for psychotic symptoms or without them;
— As an adjunct to antidepressant therapy in major depressive disorder
— The age of 18;
— Hypersensitivity to aripiprazole and other ingredients.
Patients with renal insufficiency not require correction dose. Patients with hepatic insufficiency do not require correction dose.
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