Drug Information: Indications, Side Effects, Warnings
Category:Â Men’s Health
Generic Flomax is used for treating enlarged prostate (benign prostatic hyperplasia; BPH).
Basic ingredient: Tamsulosin
The Latin name of the substance Tamsulosin
Tamsulosinum (genus. Tamsulosini)
Therapeutic agents Tamsulosin
Drugs affecting the metabolism in the prostate gland and proofreaders urodynamics
Nosological classification (ICD-10):
N40 prostatic hyperplasia
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— Selectively blocks postsynaptic alpha 1-adrenergic receptors of smooth muscles of the prostate, bladder neck and prostatic urethra.
— The ability to block the alpha 1-adrenoceptors 20 times greater (compared with the action on alfa1B adrenoceptors in vascular smooth muscle)
— Effect on systemic blood pressure slightly.
— Reduces the tone of smooth muscles of the prostate, bladder neck, prostatic urethra
— Improves the flow of urine
— Reduces the symptoms of obstruction and irritation of the urinary tract (benign prostatic hyperplasia).
The therapeutic effect develops after 2 weeks.
-practically Completely absorbed from the gastrointestinal tract (absorption 90%).
— Food intake increases the bioavailability and Cmax value
— Food intake reduces the time to reach Cmax.
— Ingestion: Cmax is reached after 4-5 h (fasting) or 6-7 hours (at reception with food).
— The equilibrium concentration is established by the 6th day course taking. Its peak is at 60-70% higher Cmax, after a single dose.
— Binding to plasma proteins (mainly alpha-1-glycoprotein) is 94-99%
— The substance is distributed over the volume of blood and extracellular fluid (volume distribution — 0.2 l / kg).
— The drug slowly biotransformed in the liver (with the participation of cytochrome P450 isoenzymes (predominantly CYP3A4 and CYP2D6) with the formation of active metabolites (retain selectivity for alpha 1-adrenergic receptors))
— Circulates in the plasma in unchanged form.
— The drug is excreted by the kidneys as metabolites conjugated with glucuronic and sulfuric acid (10% — unchanged).
— The drug is excreted in the feces in part.
Mutagenic activity was not detected in some tests.
The use of drugs:
Benign prostatic hyperplasia (treatment urinary disorders).
Hypersensitivity, orthostatic hypotension (including history), severe renal insufficiency (creatinine clearance less than 10 ml / min) and severe hepatic impairment (safety and efficacy of these categories of patients are not identified).
Pregnancy and breast-feeding:
Category effects on the fetus by FDA — B.
From the nervous system and sensory organs: Common: dizziness, headache, fatigue, drowsiness / insomnia.
Cardio-vascular system and blood (blood, hemostasis) Common: orthostatic hypotension. Rare: syncope, palpitations, tachycardia, chest pain.
From the digestive tract may be: nausea, vomiting, constipation / diarrhea.
With the genitourinary system, described cases: retrograde ejaculation, decreased libido, priapism.
Allergic reactions such as: skin rash, itching, hives, angioedema.
Others: back pain, rhinitis.
Symptoms: acute hypotension.
Treatment: giving patients lying position, the introduction of plasma substitutes or vasopressors; to stop the absorption — gastric lavage, activated charcoal or osmotic laxative.
Prices for 7-180Â capsules of generic tamsulosin 0.4 mg
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