Flomax (Tamsulosin), Buy flomax online)

Drug Information: Indications, Side Effects, Warnings

Category:  Men’s Health

Generic Flomax is used for treating enlarged prostate (benign prostatic hyperplasia; BPH).Flomax online price

Basic ingredient: Tamsulosin

The Latin name of the substance Tamsulosin

Tamsulosinum (genus. Tamsulosini)

Gross formula:

C20H28N2O5S

Therapeutic agents Tamsulosin

Drugs affecting the metabolism in the prostate gland and proofreaders urodynamics

Alpha-blockers

Nosological classification (ICD-10):

N40 prostatic hyperplasia

You can buy Generic Flomax prescription at a pharmacy or order online. Using a discount card or coupon, you get a cheaper drug. Discount is of 20-80% (depending on the pharmacy). Watch for sales, buy Generic Flomax cheaper!

Pharmacology:

— Selectively blocks postsynaptic alpha 1-adrenergic receptors of smooth muscles of the prostate, bladder neck and prostatic urethra.
— The ability to block the alpha 1-adrenoceptors 20 times greater (compared with the action on alfa1B adrenoceptors in vascular smooth muscle)
— Effect on systemic blood pressure slightly.
— Reduces the tone of smooth muscles of the prostate, bladder neck, prostatic urethra
— Improves the flow of urine
— Reduces the symptoms of obstruction and irritation of the urinary tract (benign prostatic hyperplasia).

The therapeutic effect develops after 2 weeks.

-practically Completely absorbed from the gastrointestinal tract (absorption 90%).
— Food intake increases the bioavailability and Cmax value
— Food intake reduces the time to reach Cmax.
— Ingestion: Cmax is reached after 4-5 h (fasting) or 6-7 hours (at reception with food).
— The equilibrium concentration is established by the 6th day course taking. Its peak is at 60-70% higher Cmax, after a single dose.
— Binding to plasma proteins (mainly alpha-1-glycoprotein) is 94-99%
— The substance is distributed over the volume of blood and extracellular fluid (volume distribution — 0.2 l / kg).
— The drug slowly biotransformed in the liver (with the participation of cytochrome P450 isoenzymes (predominantly CYP3A4 and CYP2D6) with the formation of active metabolites (retain selectivity for alpha 1-adrenergic receptors))
— Circulates in the plasma in unchanged form.
— The drug is excreted by the kidneys as metabolites conjugated with glucuronic and sulfuric acid (10% — unchanged).
— The drug is excreted in the feces in part.

 

Mutagenic activity was not detected in some tests.

The use of drugs:

Benign prostatic hyperplasia (treatment urinary disorders).

Contraindications:

Hypersensitivity, orthostatic hypotension (including history), severe renal insufficiency (creatinine clearance less than 10 ml / min) and severe hepatic impairment (safety and efficacy of these categories of patients are not identified).

Pregnancy and breast-feeding:

Category effects on the fetus by FDA — B.

Side effects:

From the nervous system and sensory organs: Common: dizziness, headache, fatigue, drowsiness / insomnia.

Cardio-vascular system and blood (blood, hemostasis) Common: orthostatic hypotension. Rare: syncope, palpitations, tachycardia, chest pain.

From the digestive tract may be: nausea, vomiting, constipation / diarrhea.

With the genitourinary system, described cases: retrograde ejaculation, decreased libido, priapism.

Allergic reactions such as: skin rash, itching, hives, angioedema.

Others: back pain, rhinitis.

 

Overdose:

Symptoms: acute hypotension.

Treatment: giving patients lying position, the introduction of plasma substitutes or vasopressors; to stop the absorption — gastric lavage, activated charcoal or osmotic laxative.

 

Prices for 7-180 capsules of generic tamsulosin 0.4 mg

 Buy Flomax No Prescription in pharmacy online «Together Rx Access».