Norvasc: Instructions for use, contraindications, composition

Pharmacological group

Blocker «slow» calcium channels (Calcium channel blockers)

The nosological classification (ICD-10)

I10 Essential (primary) hypertension

I15 Secondary hypertension

I20 Angina [angina]

I20.1 Angina pectoris with documented spasm

Norvasc - drug exerts antihypertensive and anti-anginal action. Release form and composition. Norvasc comes in tablet form.

Norvasc — drug exerts antihypertensive and anti-anginal action. Release form and composition. Norvasc comes in tablet form.

The drug forms

Tablets 5 mg — white or almost white, in the form of emeralds (octahedron with uneven sides) with the logo «Pfizer» on one side and «AML-5″ — on the other.

Tablets 10 mg — white or nearly white tablets in the form of emeralds (octahedron with uneven sides) with the logo «Pfizer» on one side and «AML-10″ — on the other.

Indications for use

hypertension (in both monotherapy and in combination with other antihypertensive agents);

stable angina pectoris and vasospastic angina (Prinzmetal angina or variant angina) as a monotherapy and in combination with other antianginal drugs.

Contraindications

Hypersensitivity to amlodipine and other dihydropyridine derivatives and the excipients included in the formulation;

severe hypotension (Sad less than 90 mm Hg..);

obstruction of the left ventricular outflow tract (including severe aortic stenosis;

hemodynamically unstable heart failure after myocardial infarction;

age of 18 years (effectiveness and safety have been established).

Precautions: hepatic impairment; Chronic heart failure nonischemic etiology III-IV NYHA functional class classification; unstable angina; aortic stenosis; mitral stenosis; hypertrophic obstructive cardiomyopathy; acute myocardial infarction (period and for 1 month thereafter); syndrome sick sinus (pronounced tachycardia, bradycardia); hypotension; simultaneous use with inhibitors or inducers of CYP3A4 isoenzyme.

Side effects

The frequency of adverse reactions (WHO classification): very often — more than 1/10; often — from more than 1/100 to less than 1/10; infrequently — from more to less than 1/100 to 1/1000; rarely — from more to less than 1/10000 1/1000; very rare — from less than 1/10000, including isolated reports.

From the CCC: Often — palpitations, peripheral edema (ankle and foot), rush of blood to the face; infrequently — an excessive fall in blood pressure; very rarely — fainting, shortness of breath, vasculitis, orthostatic hypotension, development or exacerbation of current CHF, cardiac arrhythmias (including bradycardia, ventricular tachycardia and atrial fibrillation), heart attack, chest pain.

From the musculoskeletal system: rarely — arthralgia, muscle cramps, myalgia, back pain, arthritis; rarely — myasthenia gravis.

From the nervous system: often — headache, dizziness, fatigue, drowsiness; rarely — fatigue, malaise, hypoesthesia, paresthesia, peripheral neuropathy, tremor, insomnia, mood lability, abnormal dreams, anxiety, depression, anxiety, tinnitus, taste perversion; very rarely — headache, increased sweating, lethargy, agitation, ataxia, amnesia.

From the digestive system: often — nausea, stomach pain; rarely — vomiting, constipation or diarrhea, flatulence, dyspepsia, anorexia, dryness of the oral mucosa, thirst; rarely — gingival hyperplasia, increased appetite; very rarely — pancreatitis, gastritis, jaundice (caused by cholestasis), hyperbilirubinemia, increased activity of hepatic transaminases, hepatitis.

From the side of hematopoiesis: rarely — thrombocytopenic purpura, leukopenia, thrombocytopenia.

With the respiratory system: rarely — dyspnea, rhinitis, nosebleed; very rarely — cough.

From the sensory organs: rarely — diplopia, disturbance of accommodation, xerophthalmia, conjunctivitis, eye pain, blurred vision.

With the genitourinary system: Infrequent — frequent urination, painful urination, nocturia, a violation of erectile function; very rarely — dysuria, polyuria.

For the skin: rarely — dermatitis; very rare — alopecia, dermatoxerasia, cold sweat, violation of skin pigmentation.

Metabolic disorders: very rarely — hyperglycemia; rarely — increase / decrease in body weight.

Allergic reactions: rarely — itching, rash (including erythematous, maculopapular rash, urticaria); very rarely — angioneurotic edema, erythema multiforme.

Laboratory findings: very rarely — hyperglycemia.

Other: rarely — fever, gynecomastia; very rarely — parosmiya.