Drug Information: Indications, Side Effects, Warnings
Category: Â Hypertension, Cardiovascular Diseases, Migraine
The drug used in the treatment of:
Hypertension, angina pectoris, sinus tachycardia (including hyperthyroidism), supraventricular tachycardia, atrial fibrillation tachysystolic, supraventricular and ventricular premature beats, hypertrophic cardiomyopathy, myocardial infarction, mitral valve prolapse, subaortic stenosis, simpatikoadrenalovy crisis in patients with diencephalic syndrome, cardiopsychoneurosis, portal hypertension, essential tremor, panic attacks, aggressive behavior, migraine (prevention), adjuvant treatment in pheochromocytoma (only in combination with alpha-blockers), hyperthyroidism (including preoperative preparation), thyrotoxic crisis, the primary weakness labor, menopausal vasomotor symptoms, withdrawal symptoms; treatment of akathisia induced by neuroleptics.
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Nosological classification (ICD-10):
F40.1 Social phobias
F40.2 Specific (isolated) phobias
F41.0 Panic disorder [episodic paroxysmal anxiety]
F41.1 Generalized anxiety disorder
F43.2 Disorder adaptive reactions
F45 Somatoform disorders
Pharmacological action — antianginal, antiarrhythmic, uterotoniziruyuschee, hypotensive.
- Blocks beta1 and beta2-adrenergic receptors
— Has a membrane-stabilizing effect
— Inhibits the sinoatrial node automaticity
— Suppresses the occurrence of ectopic foci in atria, AV compound ventricles (less)
— Reduces the speed of conduction of excitation in the AV connection to the beam Kent, mainly in the anterograde direction.
— Slows heart rate,Â buy half inderal la 80mg
— Reduces the force of heart contractions
— Reduces myocardial oxygen demand.
— Reduces cardiac output, renin secretion, blood pressure, renal blood flow and glomerular filtration rate.
— The overwhelming response of baroreceptors of the aortic arch to the lowering of blood pressure.
Influence on the formation of cancer:
it is not revealed carcinogenic properties and adverse effects on fertility.
Hypersensitivity, AV block II-III degree, sinoatrial block, bradycardia (less than 55 u. / Min), sick sinus syndrome. It is forbidden to appoint: hypotension, acute and severe chronic heart failure, Prinzmetal angina, cardiogenic shock, obliterative vascular disease, bronchial asthma.
Chronic bronchitis, emphysema, diabetes, hypoglycemia, acidosis, liver and kidney, psoriasis, spastic colitis, myasthenia gravis, pregnancy, lactation, old age.
Pregnancy and breast-feeding:
Can be used during pregnancy (if the risk to the fetus is less than the expected benefits to the mother). At the time of treatment should stop breastfeeding.
Cardio-vascular system and blood (blood, hemostasis): bradycardia, heart failure, AV block, hypotension, a violation of the peripheral circulation, thrombocytopenic purpura, leukopenia, agranulocytosis. You should consult a doctor if you experience these symptoms.
From the nervous system and sensory organs: Frequent: asthenia, dizziness, headache, insomnia, drowsiness, nightmares, reducing the rate of mental and motor responses, emotional lability, depression, agitation, hallucinations, disorientation in time and space, short-term amnesia, disturbance sensitivity, paresthesias; dry eyes, visual disturbances, keratoconjunctivitis. Perhaps you need a dose adjustment.
From the digestive tract: nausea, vomiting, abdominal pain, diarrhea or constipation, mesenteric artery thrombosis, ischemic colitis. You should immediately notify your doctor.
From the respiratory system: sore throat, chest pain, coughing, shortness of breath, and broncho laryngospasm, respiratory distress syndrome. Further taking the drug can only be under the supervision of a physician.
Over the Skin: alopecia, rash, itching, worsening of psoriasis. Should be excluded drug intolerance.
Other: withdrawal, weakening of libido, impotence, Peyronie’s disease, arthralgia, allergic reactions, lupus syndrome, hypoglycemia, fever.
Symptoms: dizziness, bradycardia, arrhythmia, heart failure. In addition, the often observed: hypotension, collapse, difficulty breathing, sometimes: acrocyanosis, convulsions. You should consult a doctor immediately.
The doctor prescribes treatment: gastric lavage and appointment of absorbent, symptomatic therapy:
-doctor prescribes: atropine, beta-agonists (isoprenaline, izadrin), sedatives (diazepam, lorazepam)
— cardiac (dobutamine, dopamine, epinephrine) vasopressor drugs means, glucagon
— may conduct transvenous pacing. Hemodialysis is ineffective.
Treatment should be under regular medical supervision. With prolonged use should consider the possibility the additional purpose of cardiac glycosides.
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