Generic Hyzaar (Losartan-hydrochlorothiazide)

Drug Information: Indications, Side Effects, Warnings

Category:  Hypertension

Generic Hyzaar is used for treating high blood pressure. Generic Hyzaar may be used to decrease the risk of stroke in certain patients with high blood pressure.

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Pharmacological group:

Antagonists of angiotensin II (AT1-subtype) in combinationHyzaar 50mg

Nosological classification (ICD-10):

I10 Essential (primary) hypertension
I15 Secondary hypertension
I50.1 Left ventricular failure


Structure and Composition:

1 film-coated tablet contains 50 mg of losartan potassium and hydrochlorothiazide 12.5 mg; in a blister pack of 14 pcs., in box 1 blister.


Active ingredients: losartan potassium hydrochlorothiazide in an amount of 12.5 mg. Auxiliary chemical compounds: microcrystalline cellulose, lactose, water, magnesium stearate, pregelatinized starch 1500.

Composition shell Gizaar: hydroxypropylcellulose, titanium dioxide, hydroxypropylmethylcellulose; added quinoline yellow aluminum lake, and 0.05 milligrams of carnauba wax.




The maximum hypotensive effect is achieved within 3 weeks after treatment. Efficiency does not depend on age and sex.

Clinical Pharmacology:

— Reduces the loss of potassium and hyperuricemia observed in isolated use of hydrochlorothiazide
— Medicine does not require dose adjustment for the elderly and patients with renal insufficiency (except severe cases)
— Preferred drug for patients who recommended combination therapy.

Indications for use:



Hypersensitivity (including derivatives of sulfanilamide), anuria, child.


You can not use the drug in the following cases:
• When anemia;
• Do not use tool in severe renal disease and liver;
• Up to the age of eighteen;
• Do not use these pills in case of hypersensitivity to the drug;
• When lactase deficiency means also contraindicated (tablets have lactose)
With careful preparation is prescribed:
— Patients with impaired water and electrolyte balance, which may develop on the background of vomiting or loose stool;
— In case of renal failure associated with renal artery stenosis;
— Diabetes mellitus;
— In the presence of hypercalcemia;
— Gout;
-with systemic pathological processes in the connective tissues, such as SLE;
— With the joint use of NSAIDs.



Pregnancy and breast-feeding:

Contraindicated in pregnancy, especially in the II and III trimester because of possible risk of developmental defects or fetal death. In the appointment during lactation should take into account the possibility of penetration into breast milk. In this regard, if necessary, should be repealed drug or stop breastfeeding.

What side effects have Generic Hyzaar?

Adverse reactions are usually mild and do not require discontinuation of treatment. Among the side effects include: coughing, diarrhea, allergic reactions such as angioedema, join vasculitis, urticaria, photosensitivity is not excluded.

There is a change of some laboratory parameters: hyperkalemia, elevated liver enzymes, usually these effects disappear after drug withdrawal.

Overdose Gizaar:

In case of overdose:

— Drop in blood pressure pronounced,
— Tachycardia or bradycardia.

The most likely symptoms:

— Hypotension and tachycardia
-It vagal bradycardia
— Hypokalemia, hypochloremia, hyponatremia, dehydration (due to increased diuresis).

Treatment of overdose:

— Maintenance treatment. Treatment is symptomatic, including correction of dehydration, electrolyte imbalance, hypotension, and the liver, with the abolition of pre-drug and gastric lavage (if the drug is taken recently).

Storage conditions of the preparation:
The temperature is not above 30 ° C (do not freeze).
Shelf life is 3 years.



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