Drug Information: Indications, Side Effects, Warnings
Category: Â Hypertension
Hydralazine is a vasodilator. Relieves spasm of the small arteries, lowers blood pressure; enhances cardiac output, heart rate speeds up; increases renal and cerebral blood flow. It works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries. Used to treat high blood pressure (hypertension).
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Therapeutic agents Hydralazine:
Nosological classification (ICD-10):
I10 Essential (primary) hypertension
I15 Secondary hypertension
I50.0 Congestive heart failure
Characteristics of substance Hydralazine:
The white crystalline powder. Soluble in water at a ratio of 4.4: 100, little — alcohol.
Structure and Composition: The preparation of synthetic origin. Release: 1) tablets and 2) dragees
Pharmacological action — hypotensive, vasodilating.
The drug inhibits transport of calcium into the cells of myofibrils arterioles and / or release of intracellular ions. Decrease in blood pressure is accompanied by a reflex increase in sympathetic tone, increased cardiac output; increases renal blood flow.
Indications for use:
Hypertension, hypertensive crisis, congestive heart failure with a high afterload, eclampsia.
The drug is absolutely contraindicated people:
— With individual intolerance
— Patients with lupus erythematosus.
Not recommended for use hydralazine:
— With a sharp expressed atherosclerotic changes in vessels of the heart and brain
— Diseases of the peripheral nerves
— Gastric ulcer
— Reduction of renal excretory function.
The drug is relatively contraindicated in people with coronary artery disease.
Side effects: There may be headache, dizziness, rapid heart rate, heart pain, excessive sweating, nausea, vomiting, watery eyes, the appearance of edema and erythematous rash. With prolonged use of hydralazine: may develop a syndrome resembling lupus erythematosus.
Pregnancy and lactation: During pregnancy only doctor decide on the possibility of using the drug. During lactation hydralazine is not contraindicated.
Interactions with Alcohol: Maybe dangerous drop in blood pressure, if you drink alcohol during treatment. .
Special instructions: The drug is not recommended for prolonged use.
Storage conditions: Store in a dry place at room temperature. Shelf life is 4 years.
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