Drug Information: Indications, Side Effects, Warnings
Category:Â Hypertension, cardiovascular diseases
Generic Altace is used for treating high blood pressure or decreasing the risk of heart attack, stroke, and death in certain patients.
Brand(s): Cardace / Cordimin / Ramzen
Manufacturer: Aventis / Ind-Swift / Zenlabs
Pharmacological group: Organotropona funds / cardiovascular agents / ACE inhibitors.
Pharmacological action: vasodilating, hypotensive, natriuretic, cardioprotective.
Generic Altace inhibits the renin-angiotensin system in tissues including walls of blood vessels in the tissue.
Generic Altace slows the release of norepinephrine and endings of neurons weakens vasoconstrictor responses, which are caused by an increase in neurohormonal activity.
Generic Altace slows the release of noradrenaline. The drug reduces the vasoconstrictor response, which caused an increase in neurohormonal activity.
Generic Altace dilates blood vessels in the kidneys.
Generic Altace reduces progression of heart failure, mortality in the remote and the early phase of myocardial infarction, the incidence of reinfarction, hospitalizations, improve patient quality of life and increase survival.
Indications for use:
Hypertension; diffuse chronic kidney disease and diabetic nephropathy; Chronic heart failure (including after acute myocardial infarction in patients with stable hemodynamics); reduce the possibility of stroke, myocardial infarction or coronary death in patients with coronary heart disease, with an increased risk of cardiovascular disease (including patients who have had myocardial infarction, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty).
Hypersensitivity (including to other ACE inhibitors), a history of angioedema, breastfeeding, pregnancy, age after 18 years (effectiveness and safety have not been identified).
Restrictions on the use:
Severe autoimmune diseases (scleroderma and other collagen system, systemic lupus erythematosus), condition after kidney transplantation, renal artery stenosis, or only hemodynamically significant bilateral renal artery stenosis, bone marrow suppression (thrombocytopenia, leukopenia), atherosclerosis of the lower extremities, malignant hypertension, lack of cerebral or coronary circulation, mitral, aortic stenosis or other obstructive changes that impede the outflow of blood from the heart; chronic obstructive pulmonary disease expressed violations of the functional state of the liver, diabetes, severe renal insufficiency (serum creatinine level at 3.5 mg / dL or 300 mmol / l) and hyperkalemia (5.5 mmol / L), sodium restriction in diet or hyponatremia, dehydration, primary aldosteronism, conducting dialysis procedures, simultaneous with saluretikami and immunosuppressants, old age.
Pregnancy and breast-feeding:
The use of ramipril is contraindicated in pregnancy.
Effect of ramipril on the fetus: lowering blood pressure in the newborn and the fetus, fetal renal developmental disorders, disturbance of renal function, hypoplasia of the skull, hyperkalemia, oligohydramnios, skull deformity, limb contractures, pulmonary hypoplasia. At the time of treatment with ramipril must to be stop breastfeeding.
Blood and circulatory system: hypotension (including postural), syncope, angina, heart failure, vertigo, heart attack, chest pain, palpitations, arrhythmia, hemolytic anemia, pancytopenia, mielodeprescia, thrombocytopenia, agranulocytosis, eosinophilia, vasculitis;
sense organs and the nervous system: dizziness, asthenia, headache, cerebrovascular disorders, drowsiness, amnesia, seizures, sleep disorders, depression, neuralgia, paresthesia, neuropathy, tremor, blurred vision, hearing loss;
Digestive system: nausea, diarrhea, vomiting, excessive salivation or dry mouth, anorexia, dysphagia, dyspepsia, abdominal pain, constipation, gastroenteritis, hepatitis, pancreatitis, changes in transaminase levels, the violation of the functional state of the liver (cholestatic jaundice, fulminant hepatic necrosis fatal);
respiratory system: non-productive cough, upper respiratory tract infection, pharyngitis, dyspnea, sinusitis, bronchitis, laryngitis, rhinitis, bronchospasm;
skin: prurigo, urticaria, rash, photosensitivity, erythema multiforme;
urogenital system: a violation of renal function, proteinuria, edema, oliguria, impotence;
Other: weight loss, increase in serum creatinine and urea nitrogen, anaphylactoid reactions, angioedema, myalgia, arthritis / arthralgia, fever, hyperkalemia, increased titers of antinuclear antibodies, changes in the concentration of bilirubin, glucose, uric acid, enzyme activity.
In case of overdose occur:
acute hypotension, angioedema, cerebrovascular accident, myocardial infarction, thromboembolism. Treatment: dose reduction or withdrawal of the drug, gastric lavage, transfer the patient to a horizontal position, taking measures to increase the volume of circulating blood (isotonic sodium chloride solution, transfusion of other blood liquids), symptomatic treatment: epinephrine (intravenous or subcutaneous), hydrocortisone (intravenous ), antihistamines.
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