Epivir (Lamivudine). Epivir uk buy online

Drug Information: Indications, Side Effects, Warnings

Category:  HIV

Clinico-pharmacological group:

The antiviral drug active against HIV

Composition, structure and packing:

Tablets, coated white, diamond-shaped, engraved with «GX CJ7″ and risks in the both sides.

The main ingredient: lamivudine 150 mg.

Other ingredients: microcrystalline cellulose 138.75 mg, 9 mg sodium carboxymethyl starch, magnesium stearate 2.25 mg.cheap pills 25mg Epivir

Cover structure: Opadry YS-1-7706-G White (59.75% hypromellose, titanium dioxide, 31.25%, 8% macrogol 400, polysorbate 80, 1%) 6.75 — 8.25 g

Epivir is a highly selective inhibitor of HIV-1 and HIV-2 in vitro. It is also active against HIV strains resistant to zidovudine. Intracellularly is metabolized to lamivudine 5′-triphosphate (active form), the half-life of the cell which is 16-19 hours.

The main mechanism of action is blocking the synthesis of the growing DNA chain during reverse transcription of HIV. Lamivudine does not violate the normal cellular DNA metabolism and has no significant effect on the maintenance of nuclear and mitochondrial DNA in mammalian cells.

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Pharmacokinetics:

absorption:

Lamivudine is well absorbed from the gastrointestinal tract. Bioavailability after oral administration is usually 80-85%. The median time to maximum concentration (Cmax) of Lamivudine serum is about 1 hr.

 

Metabolism and excretion:

On average, systemic clearance of lamivudine is 0.32 l / kg / hr. Lamivudine is excreted mainly by the kidneys (70%).

 

Dosage:

Appointment of Epivir is allowed only specialist with experience in treating HIV infection.

Epivir is used inside, regardless of the meal (before, during or after a meal).

To ensure accurate dosing of the drug is recommended to swallow pills completely without division.

 

overdose

Symptoms: In case of overdose has not been a single case of death. The status of all patients returned to normal. Any specific signs or symptoms of overdose were not.

Treatment: It is recommended: monitor the patient’s condition and perform standard maintenance therapy. Perhaps the use of continuous hemodialysis, but specific studies has been conducted.

 

 

Side effects:

Side effects occur in the treatment of HIV infection:
— Generic Epivir as monotherapy
— The combined use of Generic Epivir with other antiretroviral agents. Side effects can be caused by drugs or as a complication of HIV infection itself.

From the side of hematopoiesis: rarely — neutropenia, anemia, thrombocytopenia; very rarely erythroid aplasia of the bone marrow. Tell your doctor.

From a metabolism: often — increasing the concentration of lactic acid in the serum, rarely — lactic acidosis; Redistribution / accumulation of subcutaneous fat; frequency depends on a variety of factors, including the particular combination of antiretroviral drugs. Report these symptoms to your doctor. Require dose adjustment.

From the nervous system: often — headache, insomnia; very rarely — paresthesia; described cases of peripheral neuropathy, but the relationship of this complication with Epivir therapy has not been proven. Require dose adjustment.

On the part of the gastrointestinal tract: often — nausea, vomiting, pain in the upper abdomen, diarrhea; rarely — pancreatitis, although the relationship of this complication with lamivudine has not been proven; increased activity of serum amylase. Require dose adjustment.

On the part of the hepatobiliary system: rarely — transient increase in liver enzymes; rarely — hepatitis. Report these symptoms to your doctor.

Skin and its derivatives: often — a rash, alopecia. Require dose adjustment.

On the part of the musculoskeletal system: often — arthralgia, muscle disorders; rarely — rhabdomyolysis. Require dose adjustment.

The respiratory system and mediastinal organs: often — cough nasal symptoms. Report these symptoms to your doctor.

Other: often — fatigue, malaise, fever.

Reported cases of osteonecrosis in patients with risk factors such as late stage of HIV disease or long-term combination antiretroviral therapy (frequency of occurrence is unknown).

 

Storage conditions:

The drug should be stored at temperatures not exceeding 30 ° C, out of reach of children. Shelf life is 5 years. Do not use after the expiry date printed on the package.

Indications for use:

— HIV treatment as part of combination antiretroviral treatment of adults and pediatric patients.
Contraindications

— Hypersensitivity to lamivudine or any other component of the drug.

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