Maxolon is a drug with antiemetic action.
Release form and composition of Maxolon
The drug (Maxolon, –ú–į–ļ—Ā–į–Ľ–ĺ–Ĺ)
is available in the following dosage forms: tablets: Valium, round, white or almost white (50 pcs. In blisters, 1 package in carton box, 10 pcs. In blisters or blisters, by 1-5, 10 packs or blisters in a carton box, 14 pieces in blisters, for 4 packs in a carton box;.., 50 pieces in plastic or dark glass jars, 1 jar in a cardboard bundle); Solution for intravenous or intramuscular administration (in 2 ml ampoules by 5 or 10 vials in a carton box, or by 5 or 10 vials — plastic or of cellular contour packaging (trays), for 1 or 2 packages in cardboard package).
The composition 1 tablet of Maxolon contains:
Active ingredient: metoclopramide hydrochloride — 10 mg (as metoclopramide hydrochloride monohydrate, based on dry substance); Auxiliary components: lactose monohydrate — 60 mg; potato starch — 28.47 mg; Povidone — 0.53 mg; calcium stearate — 1 mg.
The composition of 1 ml. injectable solution comprises an active ingredient: metoclopramide hydrochloride — 5 mg.
Indications for use of Maxolon
Nausea, vomiting, hiccups, of varying etiology (in some cases, metoclopramide may be effective in the treatment of emesis induced by administration of cytotoxic drugs or radiation therapy);
Functional pyloric stenosis;
Hypotension and atony of the stomach and intestines, including post-operative;
Biliary dyskinesia of hypokinetic type;
Gastric ulcer and duodenal ulcer (an exacerbation of, in conjunction with other drugs).
— during radiopaque studies of the gastrointestinal tract (to enhance peristalsis)
— as a means of facilitating duodenal intubation (to accelerate gastric emptying, and promotion of the small intestine of food).
Absolute Contraindications of Maxolon
Stenosis of the pylorus;
Bleeding from the gastrointestinal tract;
The perforation of the stomach or intestinal walls; tumor;
Mechanical bowel obstruction;
Vomiting associated with treatment or an overdose of neuroleptics, as well as in patients with breast cancer;
Bronchial asthma amid increased sensitivity to sulfites (injectable solution);
Lactase deficiency, glucose-galactose deficiency, lactose intolerance (tablets);
I trimester of pregnancy and lactation;
Up to 2 years (any dosage forms of metoclopramide);
6 years (injectable solution);
up to 14 years (tablets);
Hypersensitivity to the drug.
Relative contraindications of Maxolon
(Used with caution in the presence of the following diseases / conditions): Asthma;
Hepatic and / or renal failure;
Children and the elderly (65 years) age;
II-III trimesters of pregnancy.
Dosage of Maxolon
Injectable solution of Maxolon (–ú–į–ļ—Ā–į–Ľ–ĺ–Ĺ)
Adults: 1-3 times a day, 10-20 mg (maximum — 60 mg per day); Children from 6 years: 1-3 times a day for 5 mg.
Pills of Maxolon
Adults: single dose — 10 mg; maximum daily — 30 mg or 0.5 mg per 1 kg of body weight; Children of 14 years: 0.1-015 mg per 1 kg of body weight per day maximum — 0.5 mg per 1 kg of body weight.
Side effects of Maxolon
Cardiovascular system: atrioventricular block;
Central nervous system: extrapyramidal disorder — trismus, spasm of the facial muscles, spasmodic torticollis, bulbar type of speech, rhythmic protrusion of tongue, the spasm of extraocular muscles (including oculogyric crisis), muscle opisthotonus, hypertonus; Parkinson’s disease (muscle stiffness, hyperkinesis, the risk of children increases in excess of 0.5 mg / kg per day), dyskinesia (chronic renal failure and in elderly patients), depression, headache, drowsiness, anxiety, fatigue, confusion, ringing in the ears;
The endocrine system: rarely (if long-term therapy with high doses) — galactorrhea, gynaecomastia, menstrual disorders;
Digestive system: diarrhea, constipation; rarely — dry mouth;
Hematopoietic system: leukopenia, neutropenia, sulfgemoglobinemiya adults;
Allergic reactions: angioedema, bronchospasm, urticaria;
Other: at the beginning of treatment — agranulocytosis; rarely (at high doses) — congestion of the nasal mucosa.
Drug Interactions of Maxolon
Ethanol: potentiation of the central nervous system;
Cholinesterase inhibitors: the weakening of the action of metoclopramide;
Hypnotics: increased sedation;
Blockers H2-histamine receptors: improving the effectiveness of therapy;
Diazepam, tetracycline, ampicillin, paracetamol, aspirin, levodopa, ethanol: increase of suction;
Digoxin, cimetidine: depot;
Antipsychotics: increased risk of extrapyramidal symptoms.
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