Nexium reduces amount of acid in the stomach and helps patients with gastroesophageal reflux disease and Zollinger-Ellison syndrome. Active ingredient: Esomeprazole
The nosological classification (ICD-10) of Nexium
K21.0 Gastro-oesophageal reflux with oesophagitis
K25 Gastric ulcer
K26 Duodenal Ulcer
K31.8.2 * gastric hyperacidity
K86.8.3 * Zollinger-Ellison Syndrome
K92.2 Gastro-intestinal bleeding, unspecified
Y45 adverse reactions in therapeutic use of analgesic, antipyretic and anti-inflammatory agents
The drug forms of Nexium
Tablets 20 mg: oblong biconvex, light pink, film-coated, engraved with «20 mgÂ» on one side and Â«A / EHÂ» — on the other.
Tablets 40 mg: oblong biconvex, pink, film-coated, engraved with «40 mgÂ» on one side and Â«A / EIÂ» — on the other.
Color on a break — white with yellow patches (cereal type).
Indications for use of Nexium
gastroesophageal reflux disease:
— Treatment of erosive reflux esophagitis;
— Long-term maintenance therapy after healing of erosive reflux esophagitis to prevent relapse;
— Symptomatic treatment of gastroesophageal reflux disease;
gastric ulcer and duodenal ulcer (in a combination therapy):
— Treatment of duodenal ulcer associated with Helicobacter pylori;
— Prevention of relapse of peptic ulcers associated with Helicobacter pylori;
long-term therapy in patients undergoing bleeding from peptic ulcers (after / in the use of drugs, reducing the secretion of gastric glands) for relapse prevention;
Patients taking NSAIDs for a long time:
— Healing of gastric ulcers associated with NSAID;
— Prevention of gastric and duodenal ulcers associated with NSAIDs, in patients at risk;
Zollinger-Ellison syndrome and other conditions characterized by pathological hypersecretion of gastric glands, including idiopathic hypersecretion.
Contraindications of Nexium
Hypersensitivity to esomeprazole, substituted benzimidazoles or other ingredients included in the formulation;
hereditary fructose intolerance, glucose-galactose malabsorption or sucrase-izomaltaznaya failure;
concomitant use with atazanavir and nelfinavir (see «Interaction».);
Children up to age 12 years (due to lack of data on efficacy and safety of the drug in this patient group);
children older than 12 years (for other indications, except gastroesophageal reflux disease).
Precautions: severe renal insufficiency (application experience is limited).
Side effects of Nexium
The frequency of side effects is given by the following grading: very common (â‰Ą1 / 10); commonly (â‰Ą1 / 100, <1/10); uncommon (â‰Ą1 / 1000, <1/100); rare (â‰Ą1 / 10,000, <1/1000); very rare (<1/10000).
Skin and subcutaneous tissue disorders: uncommon — dermatitis, pruritus, rash, urticaria; rare — alopecia, photosensitivity; very rarely — erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
On the part of the musculoskeletal and connective tissue disorders: rarely — arthralgia, myalgia; rarely — muscle weakness.
From the nervous system: often — headache; Infrequent — dizziness, paresthesia, drowsiness; rarely — a violation of taste.
Mental disorders: rarely — insomnia; rarely — depression, agitation, confusion; very rarely — hallucinations, aggressive behavior.
On the part of the digestive tract: often — abdominal pain, constipation, diarrhea, flatulence, nausea / vomiting; Infrequent — dry mouth; rarely — stomatitis, gastrointestinal candidiasis; very rarely — microscopic colitis.
On the part of the liver and biliary tract: rarely — increase in liver enzymes; rarely — hepatitis (with or without jaundice); very rarely — liver failure, encephalopathy in patients with liver disease.
From the genitals and breast: it is very rare — a gynecomastia.
From the blood and lymphatic system: rarely — leukopenia, thrombocytopenia; very rarely — agranulocytosis, pancytopenia.
Immune system: rarely — hypersensitivity reactions (eg fever, angioedema, anaphylactic reaction / anaphylactic shock).
The respiratory system, organs, thoracic and mediastinal disorders: rarely — bronchospasm.
On the part of the kidney and urinary tract: very rarely — interstitial nephritis.
On the part of the organ of vision: rarely — blurred vision.
On the part of metabolism and nutrition: rarely — peripheral edema; rarely — hyponatremia; very rarely — hypomagnesemia; hypocalcemia due to severe hypomagnesemia, hypokalemia, hypomagnesemia due.
General disorders: rarely — malaise, sweating.