Drug Information: Indications, Side Effects, Warnings
Category: Â Gastrointestinal Tract
Generic Imodium is used for treating symptoms of certain types of diarrhea, Loperamide used to decrease the amount of discharge from an ileostomy.
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Antidiarrheals. Lowers the tone and motility of the smooth muscle of the intestine (by binding to opioid receptors in the gut wall). The drug inhibits the release of acetylcholine and prostaglandins, reducing peristalsis and increasing the time of the contents of the intestines.
The drug increases the tone of the anal sphincter. The action comes fast and lasts 4-6 hours.
After oral administration, the absorption of loperamide is about 40%. The drug undergoes extensive metabolism in the «first pass» through the liver. A small amount of unmodified loperamide enters the systemic circulation. Do not cross the BBB.
Metabolized in the liver:
T1 / 2 is 9-14 hours. The drug is excreted through the bile in the feces in the form of conjugated metabolites, a small portion is excreted in the urine.
In adults with acute diarrhea the first dose is 4 mg, then — 2 mg after each act of defecation (in the case of loose stool). In chronic diarrhea the first dose is 2 mg. The maintenance dose is adjusted individually (2-12 mg / day).
The maximum daily dose for adults is 16 mg.
For children aged 4-8 years appoint 1 mg 3-4 times / day for 3 days; children 9-12 years: appointed to 2 mg 4 times / day for 5 days — imodium loperam 2mg cap 10.
Pregnancy and lactation:
The drug is contraindicated in the I trimester of pregnancy. You can receive under the supervision of a physician in II and III trimester of pregnancy.
A small amount of loperamide is found in breast milk, so the medication during breastfeeding is not recommended.
From the digestive system: abdominal pain, bloating, nausea, constipation, dry mouth.
If you have these symptoms, you should consult your doctor.
CNS: fatigue, drowsiness, dizziness.
Allergic reactions: skin rash.
Indications for use:
Symptomatic treatment of acute and chronic diarrhea of various origins (including allergic, emotional, drug, radiation. It is used when changing the supply and quality of food, in violation of metabolism and absorption, the drug is used as an adjunct in the diarrhea of infectious origin). The drug is used in the Regulation of stool in patients with ileostomy.
Bowel obstruction; constipation, bloating, subileus, acute dysentery (as monotherapy), acute ulcerative colitis, pseudomembranous colitis, caused by the use of broad-spectrum antibiotics; Children under 4 years old, I trimester of pregnancy, hypersensitivity to loperamide.
When liver failure, use with caution.
Should not be used in clinical situations where inhibition of intestinal motility.
If no effect after 2 days of application, it is necessary to clarify the diagnosis. Not to be used in infectious diarrhea genesis.
Used with caution in patients with impaired liver function.
In case of overdose is using naloxone.
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