Revatio works by relaxing blood vessels and improves blood flow in the penis causing erection.
Composition of Revatio
active substance of Revatio
Sildenafil (as sildenafil citrate) 20 mg
Other ingredients: MCC — 62.632 mg; calcium hydrogen phosphate — 20.878 mg; Croscarmellose sodium — 6 mg; Magnesium stearate — 2.4 mg
shell film: Opadry White II OY-LS-28914 (hypromellose, titanium dioxide, lactose monohydrate and triacetin) — 3 mg; Opadry clear YS-2-19114-A (hypromellose and triacetin) — 0.9 mg
Contraindications of Revatio
Hypersensitivity to any component of the drug;
combined use with nitric oxide donators or nitrates in any form;
concomitant use with strong inhibitors of CYP3A4 isoenzyme (including ketoconazole, itraconazole, and ritonavir) (see section «Interactions».);
loss of vision in one eye as a result of the front nearteriitnoy ischemic optic neuropathy;
hereditary degenerative eye disease of the retina (retinitis pigmentosa);
severe liver dysfunction (more than 9 points on a scale Child-Pugh);
stroke or myocardial infarction;
severe hypotension (Sad less than 90 mm Hg, DBP less than 50 mmHg….);
lactose intolerance, lactase deficiency, glucose-galactose syndrome malabsorption;
age of 18 years (the study of efficacy and safety have not been conducted).
Be wary: I or IV PAH functional classes; anatomical deformation of the penis (angulation, cavernous fibrosis or Peyronie’s disease) and diseases that predispose to the development of priapism (sickle-cell anemia, multiple myeloma, leukemia); diseases accompanied by bleeding, or exacerbation of gastric ulcer and duodenal ulcer; heart failure, unstable angina, life-threatening arrhythmia, hypertension (blood pressure more than 170/100 mm Hg..), obstruction of the left ventricular outflow tract (aortic stenosis, hypertrophic obstructive cardiomyopathy); rarely occurring syndrome of multiple system atrophy manifesting severe dysregulation of blood pressure on the part of the autonomic nervous system, hypovolemia; nearteriitnaya anterior ischemic optic neuropathy in history; joint application with moderate inhibitors of CYP3A4 isoenzyme (including erythromycin, saquinavir, clarithromycin, telithromycin and nefazodone) and Î±-blockers; joint application with inducers of CYP3A4 isoenzyme.
Take one Revatio tablet of 20 mg three times a day with or without food. Each dose should be divided by 4-6 hours. Regular intakes of the medication separated by equal time periods are preferable.
Side effects of Revatio
Side effects on the MedDRA system organ classification and frequency: very common — â‰Ą1 / 10; often — â‰Ą1 / 100, <1/10; rarely — â‰Ą1 / 1000, <1/100; very rarely — <1/1000; Frequency not known (can not be determined on the basis of available data).
Infections and infestations: common — inflammation of the subcutaneous tissue, flu, sinusitis, unspecified.
From the blood system and the lymphatic system: often — anemia, unspecified.
Metabolism and nutrition: common — fluid retention (edema).
Mental disorders: often — insomnia, anxiety.
On the part of the central nervous system: very often — headache; often — tremor, paresthesia, burning sensation, unspecified, hypoesthesia; the frequency is unknown — a migraine.
From a sight organ: often — hemorrhage in the retina, unspecified visual impairment, blurred vision, photophobia, hromatopsiya, tsianopsiya, inflammation of the eye, redness of the eye; rarely — blurred vision, diplopia, disturbance of sensitivity of the eye.
On the part of the organ of hearing and labyrinth disorders: often — vertigo; the frequency is unknown — sudden deafness.
Vascular disorders: very often — flushing (redness of the skin); the frequency is unknown — blood pressure reduction.
Respiratory system, thoracic and mediastinal disorders: often — unspecified bronchitis, epistaxis, rhinitis, unspecified, cough, nasal congestion.
On the part of the digestive tract: often — diarrhea, dyspepsia; often — unspecified gastritis, unspecified gastroenteritis, gastroesophageal reflux disease, haemorrhoids, abdominal distension, dryness of the oral mucosa.
Skin and subcutaneous tissue disorders: often — alopecia, erythema, increased sweating at night; the frequency is not known — skin rash.
On the part of the musculoskeletal system and connective tissue: very often — pain in the extremities; often — myalgia, back pain.
Reproductive system and breast: often — gynecomastia, gemospermiya; the frequency is unknown — priapism, a prolonged erection.
General disorders and administration site reactions: often — fever.
The drug relaxes blood vessels which are able to transfer more blood and oxygen reducing pulmonary blood pressure. Its active substance is sildenafil, the same as in Viagra. That is why Revatio can be used in treatment of men’s health.