Therapeutic substance of Megalis
The nosological classification (ICD-10)
F52.2 Lack of genital response
Mode of action — improving erectile function.
An erection during sexual stimulation is caused by increased blood flow to the tissues of the penis. This is due to smooth muscle relaxation of cavernous bodies and arteries.
Macleods Pharmaceuticals manufactures Megalis 20. The 20mg powered Tadalafil composed drug helps impotent men to deal with Erectile Dysfunction.
Megalis improved erectile function (compared to placebo), the effect manifests as from 16 minutes and continued for 36 h after administration.
Contraindications of Megalis:
simultaneous reception of organic nitrates in any form;
co-treatment of alpha-blockers (except 0.4 mg of tamsulosin 1 times a day).
Restrictions apply to:
Cialis is not indicated for use in women and children (tadalafil are not evaluated in patients under 18 years old), newborn.
Diseases of the cardiovascular system:
— A myocardial infarction within the preceding 90 days;
— Unstable angina or angina occurring during sexual intercourse;
— Heart failure (class II and higher NYHA classification), which developed during the last 6 months;
— Uncontrolled cardiac arrhythmias, hypotension (blood pressure <90/50 mmHg..), Or uncontrolled hypertension;
— Stroke, transferred within the last 6 months.
— Diagnosed hereditary degenerative retinal disorders.
— The predisposition to priapism (sickle-cell anemia, multiple myeloma, leukemia), anatomical deformation of the penis (angulation, cavernous fibrosis, Peyronie’s disease).
— Severe hepatic impairment.
Headache, back pain, nasal congestion, flushing, pain in extremity, myalgia.
Common: asthenia, face edema, fatigue, pain.
Cardio-vascular system: angina, chest pain, hypotension, hypertension, myocardial infarction, orthostatic hypotension, palpitations, syncope, tachycardia.
From the digestive tract: changes in the functional liver samples, diarrhea, dry mouth, dysphagia, esophagitis, gastroesophageal reflux disease, gastritis, increased gamma glutamyl, loose stools, nausea, abdominal pain at the top, and vomiting.
From the musculoskeletal system: arthralgia, pain in the neck.
From the nervous system: dizziness, hypoesthesia, insomnia, paresthesia, somnolence, vertigo.
From the respiratory system: dyspnea, epistaxis, pharyngitis.
Dosage ofÂ Megalis
Inside, regardless of meals, the initial dose — 20 mg. The maximum recommended frequency of administration — one time per day.
In older men (65 years and older): initial dose — 20 mg.
Renal failure: the initial dose — 20 mg Megalis.
At moderate renal insufficiency (Cl creatinine 31-50 ml / min), the recommended initial dose — not more than 5 mg per day; the maximum dose — not more than 10 mg every 48 hours In severe renal failure patients on hemodialysis, the maximum recommended dose -. not more than 5 mg per day.
Abnormal liver function. When liver failure (mild to moderate severity), the maximum dose is 10 mg 1 time per day. In severe hepatic insufficiency: the use of the drug is not recommended.
For the skin: rash, itching, sweating.
On the part of the organs of vision: blurred vision, changes in color vision, conjunctivitis (including conjunctival hyperemia), eye pain, increased lacrimation, swelling of the eyelids.
With the genitourinary system: increased erection, spontaneous erection.
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