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Drug Information: Indications, Side Effects, Warnings

Category:  Erectile dysfunction

Tadalafil was developed by the British pharmaceutical company Elly Lilly. This drug is an agent for the treatment of male erectile dysfunction. Tadalafil relaxes blood vessels and blood supply of tissues of the penis is enhanced, resulting is a good erection. British corporation produces a drug with tadalafil (an active ingredient), called Cialis.

There are about 10 products containing Tadalafil. But only one original drug — Cialis. All others are generic.order Tadalafil 5mg

Tadalafil is a chemical. It does not occur in foods or in the nature. The substance obtained by in vitro chemical means.

Experts of the British Pharmaceutical corporations have developed a method of producing and chemical synthesis of tadalafil in 2013. Pharmacologists created an original drug Cialis on the basis of the substance. During the development of the original drug, pharmaceutical concern synthesizes and releases certain chemicals, which will be active component. Optimal dosages of the substance are established experimentally. At these doses the drug has the best positive effect with minimal side effects. Optimal auxiliary components selected in the same manner.

Experts are developing technology of synthesis of substance and methods for purification of various impurities. Impurities cause allergic reactions and side effects. Upon successful completion of all stages of development, the finished product is tested. The drug gets its original name, and goes on sale. These original pharmaceuticals have international patents. The patent for the drug is valid for a limited time. Thereafter, a pharmaceutical company may use structure the original drug (written in each statement) and do (according to the prescribed dose) own medicine. This drug will be called generics.

New drug has a new name rarely. And most new drugs are named on the international name of the active ingredient. For example: the original drug called Cialis, and most generics — Tadalafil. In Generics contain the same active ingredient as in the original drug. Generics usually cost much cheaper than the original drugs.

Sometimes pharmacists use not those auxiliary substances which are in the original drug. Auxiliary substances not undergo careful processing and can cause more severe side effects.

To date, Tadalafil is available in tablet form. The dosage of active ingredient is as follows: 2.5 mg, 5 mg, 20 mg (generic tadalafil 20mg) and 40 mg. The active ingredient in drugs, «Tadalafil» is a chemical substance with the same name — Tadalafil. Other ingredients: lactose; giproloza; croscarmellose sodium; microcrystalline cellulose; magnesium stearate; sodium lauryl sulfate; titanium dioxide; triacetin.
Tadalafil is a drug that improves male erection. The drug acts on the main reactions that make up a single process of sexual arousal. As a result, the penis comes in erection.

Usually, when a man is sexually excited, the penis blood vessels dilate much. Increases blood flow to the penis, which becomes dense. So there comes an erection. If the patient has a different erectile dysfunction, then it is defective blood supply vessels of the penis. Tadalafil is a drug, which increases the blood circulation in the penis (that creates a stable and good erection). Tadalafil does not act alone. Sexual stimulation and natural sexual arousal affect the operation of the drug. The drug can not make the blood vessels to expand, filled with blood and make erection without sexual stimulation.

Normal sexual stimulation sends impulses to the appropriate centers in the spinal cord and brain. This center commands the release of nitric oxide at the nerve fibers. Tadalafil can only enhance and prolong the action of cGMP. The drug makes the erection more pronounced and prolonged. In the absence of sexual stimulation, the drug will not cause the penis in erection. The drug is only strengthens and extends the natural process. The drug can not artificially create sexual arousal and cause an erection in men.

PDE enzymes are located not only in the blood vessels of the penis. Enzymes are in retinal arteries, skeletal and cardiac muscle, lung, etc. PDE in each organ is designated a specific number. Tadalafil has a high specificity. It affects only the PDE-5 (an enzyme of the penis).

The drug has no side effects, such as an increase or decrease in pressure, change of color, etc. (Like Viagra, which has no such specificity).

The drug works within 36 hours after taking the pill. The drug starts working after 16 minutes after taking the pill (with good sexual arousal); Acts the same way when lying down and standing.

 

Indications for use:
— Treatment of erectile dysfunction (a condition in which the penis does not become sufficiently dense and excited for a full intimate contact. The drug causes the development of a good erection only in combination with sexual stimulation).

— Use with weak erections (which is caused by: psycho-emotional disorders, organic erectile dysfunction, diabetes, removal of the prostate, obesity, hypertension, spinal cord injury).
Contraindications:
Tadalafil has the absolute and relative contraindications. If you have absolute contraindications, so you can not take the drug under any circumstances. And if you have relative contraindications, you can use the drug with a careful monitoring of health.
Absolute contraindications:
— Sensitivity, allergies or intolerance of tadalafil and other components of the drug
— Age under 18 years
— Pregnancy
— Breast-feeding
— Taking of drugs containing nitrates (Molsidomine, sodium nitroprusside, nitroglycerin, Nitrosorbid, Tivortin, Vazotropin etc) during treatment
— Taking alpha-blockers ( Tropafen, phentolamine, phenoxybenzamine, pirroksan, Afluzozin, Butiroksan, Ditamin, doxazosin, Nicergoline, Prazosin, etc.) during treatment.

 

Relative contraindications to the use of tadalafil:
— Heart failure class II and above, which has developed in six months
— Liver failure
— Unstable angina
— Angina, developing during lovemaking
— Renal failure with creatinine clearance less than 50 ml / min according to the sample Rehberg
— Hypotension lower than 90/50 mm Hg. Art.
— A heart attack or stroke, myocardial in the last six months
— Degenerative diseases of the retina, such as retinitis pigmentosa
— Sickle cell anemia Multiple myeloma Leukemia
— Deformation of the penis (curvature, fibrosis, Peyronie’s disease)
— The combined use with other PDE — 5 (Viagra)
— Uncontrolled hypertension or arrhythmia
Instructions for use

— The tablet is ingested orally
— Tablet washed down with water
— The drug is taken regardless of meals.

— Take no earlier than 16 minutes before sexual intercourse.

— The drug works 36 hours

— The drug is taken not more than 1 time per day

— People older than 65 years should take Tadalafil in the usual dosages

— The dosage can be reduced to 10 mg, 5 mg or 2.5 mg. If there is an urgent need to feel confident, it is allowed to take 40 mg at a time.

— 40 mg is the maximum daily dose of the drug

— It is theoretically possible occurrence of the disease priapism — an erection, causing pain (persists for a long time (several hours)).

— With the development of side effects, the patient should immediately consult a doctor. Late treatment of this condition can lead to a loss of potency in the future for a long period of time.

— Do not use tadalafil for women.

 

In renal insufficiency:

-Patients Takes the drug in the usual dosage with little functional disorders of the kidneys.

- In patients with moderate renal impairment is recommended to start with a dose of tadalafil 5 mg. The maximum allowable dosage for this category of people is 10 mg over 48 hours.

— In severe renal failure, the maximum allowable daily dose is 5 mg tadalafil.

If you experience back pain — see a doctor.

 

 

Patients suffering from liver failure

 

In mild or moderate hepatic failure, drug can be taken at a dosage of 10 mg per day. If severe hepatic impairment, it is recommended to refrain from tadalafil.

 

Overdose.
Research has shown that taking 500 mg per once, or 1000 mg for several times in one day does not cause symptoms of an overdose.
If the patient has negative, strongly pronounced side effects, the doctor prescribes a symptomatic treatment.

 

Drug interactions:

Enhance the effect:

 

— Inhibitors of the enzyme CYP3A4 (tetracycline, ketoconazole, itraconazole, erythromycin, cimetidine, saquinavir, ritonavir, clarithromycin, telithromycin, nefazodone, and so on)

— Donator of nitric oxide (nitroglycerin, sodium nitroprusside, Molsidomine, Nitrosorbid, Tivortin, Vazotropin etc.)

— Alcohol
— Viagra

Reduce the effect of:

 

— Rifampicin
— H2 — histamine (e.g. kvamatel et al.)

 

The most common side effects are:

 

headache; tadalafil cialis from india — dyspeptic symptoms (belching, abdominal pain, heartburn, diarrhea, etc.); back pain; muscle pain; nasal congestion; tides; pain in the limbs; swelling of the eyelids; pain in the eyes; redness of the conjunctiva of the eye; dizziness.

 

Pains usually occur in the lower part of the waist, buttocks, hips, tailbone or sacrum.

Theoretically Possible side effects:
— The whole body: Asthenia, swelling of the face, fatigue, pain.

 

Cardiovascular System: Angina pectoris, chest pain, reduced or elevated pressure, myocardial infarction, palpitations, syncope
Digestive system: Changes in AST and ALT, diarrhea, dry mouth, difficulty swallowing (dysphagia), esophagitis, gastritis, increased activity of gamma-glutamyl, nausea, vomiting, pain in the stomach.

 

Musculoskeletal system: joint pain, pain in the neck.

 

Nervous System: dizziness, increased sensitivity of the skin, insomnia, somnolence, paresthesia (a feeling downhill «chills», etc.)

 

Skin: rash, itching, sweating.

 

Eyes: buy tadalafil 270 online — Violations of visual acuity, color perception Violation, conjunctivitis, eye pain, tearing, swelling of the eyelids.

 

Urogenital: Increased erection and spontaneous erections.

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You can buy the drug from a pharmacy or order online. If you want to buy tadalafil cheaper, you can use a coupon or discount card. Discount will allow you to buy the drug at the best price. Also online you can buy tadalafil no prescription. Prices in the online store may differ from the pharmacy. The drug may be on sale. Stocks allow you to buy the cheapest generic tadalafil online 20mg x 90 drugs.

 

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