Drug Information: Indications, Side Effects, Warnings
Category:Â Erectile Dysfunction
Kamagra is the special medication which is used to treat various types of erectile dysfunction, it has sildenafil as main active ingredient thus also is known as kamagra sildenafil. This medication is manufactured in two forms generally: kamagra soft tabs, and few kamagra chewable forms such as kamagra gel and kamagra oral jelly. The chewable forms have few tastes, two main are pineapple and orange. It was discloswed that each 5 g of kamagra pills contains sildenafil citrate as active ingredient (10,240 mg which is equivalent to sildenafil 50 mg and 140,480 mg which is equivalent to sildenafil 100 mg). Additional ingredients include saccharose, natrimethylparahydroxybenzoate, sodium propylparahydroxybenzoate, potassium acesulfame, sodium chloride, propyleneglycol, liquid sorbite (70%), sodium carmellose, anhydrous citric acid, citric acid monohydrate, FCF (Đ•110), RSV (IFF), WS(Đ•104), purified water.
So what is kamagra in general? Basically you may order kamagra jel or kamagra oral jelly, orange colour means it has orange flavour, and yellow colour means it has pineapple flavour. Both forms of kamagra uk are sweet and have nice aroma.
One of the advantages of this particular medication is that kamagra fast ability to be absorbed. The maximum concentration of kamagra 100mg in plasma can be observed within time frame from 30 up to 120 minutes with average 60 minutes, if the kamagra 100 was taken orally without food intake. Taking kamagra fast tablets along with oily and fatty food will lead to a significant decrease in sildenafil absorption. It was confirmed by many studies that sildenafil and its main metabolite N-dysmethyl are fused with plasma proteins on 96%, but such fusion depends on general kamagra concentration in the blood stream.
The main metabolic path for the kamagra 100mg oral jelly works with liver microsomal isoferments CYP 3A4, the secondary metabolic path works with CYP2C9. Process of N-dysmethilation leads to a breakdown of active ingredients of kamagra jelly to active metabolite, which is being excreted later. This particular kamagra metabolite possesses selective action against PDE-5 and its in vitro activity towards PDE-5 compare to the initial medication is approximately 50%. Sildenafil metabolites are excreted with faeces (up to 80%) and urine (up to 13%).
According to kamagra reviews, the medicine contains sildenafil citrate, which is known selective inhibitor of cyclic guanosinemonophosphate (specific PDE-5). Physiological mechanism of human erection include release of nitrogen oxide in cavernous body of the penis during sexual arousal. The nitrogen oxide activates such enzyme as guanilatcyclase which in turn, leads to increase in levels of cyclic guanosinemonophosphate with following relaxation of unstriated muscle inside the cavernous body, which provides blood inflow. Meanwhile none of the forms of this medicine, including kamagra gold, has no direct relaxing action onto cavernous body in human organism, still it can enforce the nitrogen oxide action by inhibition of PDE-5. That is why it is worth to be noted that according to all kamagra oral jelly reviews the drug in recommended dosage does not trigger erection if there is no natural sexual arousal.
Indications and dosage for super kamagra
Indications for the kamagra 100 include treatment of erectile dysfunction of any etiology and also improvement of current erection. One sachet of kamagra gold is meant for one oral intake only, you need to open it and use all the content immediately. It is worth to remember that kamagra should be taken only under doctorâ€™s observation, however, it can be prescribed in clinic and then be bought in pharmacy, you also can buy kamagra online. Kamagra for sale can be found in various online pharmacies so one should look following words for the search engines: kamagra uk, kamagra usa, kamagra kaufen, online kamagra, kamagra deutschland. Certain hypermarkets offer kamagra oral jelly over the counter.
For the vast majority of patients the recommended dosage is 50 mg (kamagra 50), it is should be take when needed approximately one hour before the supposed sexual activity. However, it is allowed to take the required dose in such interval as from four hours to half an hour before sexual intercourse. The maximum dose of kamagra soft form is 100 mg, it can be taken once a day only.
Warning! The following factors are linked to an increase of sildenafil levels in plasma:
- Age above 65 years (40% increase of AUC);
- Liver failure, for example, cirrhosis (80% increase of AUC)â€™
- Severe kidney failure with creatinine clearance less than 30 ml/min (100% increase of AUC):
- Simultaneous intake of strong cytochrome P4503A4 inhibitors like erythromycin, ketoconazole, itraconazole (200% increase of AUC). Since high concentration of such component in plasma may lead to increase effectiveness along with kamagra side effects, therefore, initial dose for such patients should not exceed 25 mg and be taken only under medical supervision. The kamagra 100 mg can never be given to these patients.
Kamagra oral jelly side effects can be divided into the following groups:
- Happen very often (headache, migraine);
- Happen often (dizziness, mild short-term vision impairment, usually blur vision and alteration of colours perception, high sensitivity to light, blood inflow to face, rhinitis, flu syndrome, dyspepsia);
- Happen seldom (corectasia, conjunctivitis, photophobia, ophthalmalgia, eyes hemorrhage, cataract, ear noise, ear pain, wheeze, cough, laryngitis, pharyngitis, sinusithis, bronchitis, asthma, rapid heartbeating, tachycardia, syncope, hypotony, postural hypertension, peripherial edema, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, visible ECG deviances, atrioventricular heart block, cardiac angina, cardiomyopathy, dry mouth syndrome, thirst, vomiting, stomatitis, gingivitis, glossitis, dysphagy, esophagitis, gastritis, gastroenteritis, colitis, rectal hemorrhage, chest pain, fatigue, lumbar pain, podagra, arthralgia, myalgia, tendon rupture, tendovaginitis, myasthenia, synovitis, arthritis, arthrosis, ataxia, neuralgia, neuropathy, paresthesia, tremor, depression, sleepiness, insomnia, sleep deprivation, reduction of response, hypersthesia, urticaria fever, common herpes, skin rashes, intense itching, excessive sweating, skin ulcers, contact dermatitis, cystitis, nycturia, polyuria, uroclepsia, breast emlargement, impairment of ejaculation, genitals swelling, anorgazmia, anaemia, leukopenia, hyperglycemia, hypoglycemia, hyperuricemia, hypernatriemia);
- Happen very seldom (cerebrovascular impairment, loss of consciousness, hearing loss, myocardial infarct, atrial fibrillation, hypertension, nose bleeding).
The main kamagra contradictions consist of the following:
- High sensitivity towards any ingredient of the kamagra;
- Simultaneous intake kamagra with nitrogen oxide donators, organic nitrates or nitrites in any form;
- Heart failure;
- Unstable angina, or myocardial infarct which took place within last six months;
- Stroke and severe atrial fibrillations;
- Hypertension above 170/100 or hypotony below 90/50;
- Congenital degenerative retina diseases like rhetinitis pigmentosa, congenital defect retinal PDE;
- Minor age as children and adolescents;
- Being female.
Interaction with other drugs
It is known that inhibitors of cytochrome P450 isoforms may have specific impact on sildenafil clearance. Cymretidin, a non-specific CYP-inhibitor triggers 56% increase of sildenafil (50 mg) concentration in plasma, how few studies have shown already. The stronger inhibitors like ketoconazole and itraconazole may have stronger impact. Intake of antacid has no impact on sildenafil concentration, as well as butamid, warfarin, SSRI antidepressants, thiazide-type inhibitors and alike diuretics.
It is important to check the individual medical history before making a decision to buy kamagra oral jelly, also would be great to look for some information in kamagra wiki article. Also the full physical examination is required in order to diagnose potential main reasons of developed erectile dysfunction and decide on the adequate treatment.
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