CIALIS (Tadalafil) tablets. Cialis free trial pack

Drug Information: Indications, Side Effects, Warnings

Category:  Erectile dysfunction

Cialis is a drug that is used to treat erectile dysfunction. The main ingredient of the drug is Tadalafil. The drug causes a rush of blood to the genitals. Cialis is used to treat various types of erectile dysfunction, including psychological, neurological, medical and other erectile dysfunction. The drug is taken once a day. Before taking this medication, you should consult a physician.cialis pills 30mg
ATC
G04BE08 Tadalafil

Pharmacological group:

Agent for the treatment of erectile dysfunction, PDE-5 inhibitor [Regulators potency]

Nosological classification (ICD-10):

F52.2 Lack of genital response
N40 prostatic hyperplasia

 

Active ingredient: 5 mg tadalafil
Other ingredients: lactose monohydrate — 109.65 mg; lactose monohydrate (spray dried) — 17.5 mg; giproloza — 1.22 mg; giproloza (extra thin) — 2.8 mg; Sodium lauryl sulfate — 0.49 mg; MCC — 26.25 mg; Croscarmellose Sodium — 11.2 mg; magnesium stearate (vegetable) — 0.88 mg
coated tablet: Opadry Yellow (Y-30-12863-A) — 8,75 mg (lactose monohydrate — 3.72 mg hypromellose — 2.59 mg titanium dioxide — 1.54 mg Triacetin — 0.74 mg dye iron oxide yellow — 0.16 mg).

 

Pharmacological action:
— Improves erectile function.

 

How does Cialis?

Tadalafil is a reversible selective inhibitor of specific PDE5 cGMP.

  1. Sexual stimulation causes local release of nitric oxide
    2. Inhibition of PDE5 tadalafil leads to increased concentrations of cGMP (in the corpus cavernosum of the penis).
    3. There is a relaxation of smooth muscles of arteries.
    4. Increasing blood flow to the tissues of the penis
    5. There comes an erection.

Cialis has no effect in the absence of sexual stimulation.

 

Tadalafil is a selective inhibitor of PDE5. PDE-5 is an enzyme located in the smooth muscle of the corpus cavernosum in vascular smooth muscle organs, skeletal muscle, platelets, kidneys, lungs and cerebellum. An effect of tadalafil for PDE5 is more active than for other PDE.

 

Tadalafil improves erection and increases the possibility of full sexual intercourse.

 

Cialis has no effect on visual acuity, electroretinogram, intraocular pressure and pupil size as Viagra.

 

Pharmacokinetics:

Absorption:
Rapidly absorbed after oral administration. The mean Cmax in plasma is reached after 2 h after ingestion. The rate and extent of absorption is not dependent on the food intake, medication Cialis® therefore can be used regardless of the meal. Time of taking the pill (morning and evening) did not affect the rate and extent of absorption.
Css in plasma reached within 5 days of taking the drug at one time per day.
Average Vd is about 63 liters (tadalafil is distributed into body tissues).
At therapeutic concentrations, 94% binds to plasma proteins.
In healthy individuals: less than 0.0005% — 20mg buy cialis of the taking dose was found in semen.

Special populations:

Elderly patients. Healthy older patients (65 years or over) had a lower clearance of tadalafil ingestion. It is expressed in an increase in AUC by 25% (compared with healthy individuals aged 19 to 45 years). This difference is not clinically significant and does not require dose adjustment.

Patients with renal failure.
It is does not require dosage adjustment in patients with renal insufficiency mild to moderate severity. Patients with severe renal impairment are not recommended Cialis®.

Patients with hepatic insufficiency. In appointing the drug Cialis® patients with severe hepatic insufficiency, you must first to assess the risks and benefits of the drug.

Patients with diabetes mellitus. AUC (in diabetic patients) is less than about 19% (than in healthy individuals). This difference does not require dose.

Indications drug Cialis®:

— Erectile dysfunction (ED);

— lower urinary tract symptoms in patients with benign prostatic hyperplasia;

— erectile dysfunction in patients with lower urinary tract symptoms of benign prostatic hyperplasia.

 

 

Contraindications:

— hypersensitivity to tadalafil or any substance that is part of the preparation;

— administration of drugs containing any organic nitrates;

— use by persons under 18 years of age;

-loss of vision due nearterialnoy anterior ischemic optic neuropathy (regardless of communication with the reception PDE5 inhibitors);

-concomitant use of doxazosin as well as drugs for the treatment of erectile dysfunction;

-frequent (more than 2 times a week) use in patients with chronic renal insufficiency (Cl creatinine <30 ml / min);

-lactase deficiency, lactose intolerance, glucose-galactose malabsorption;

— contraindications to sexual activity in patients with CVD (buy cialis uk) (myocardial infarction within the last 90 days, unstable angina, the occurrence of angina attack during sexual intercourse, chronic heart failure class II-IV classification NYHA, uncontrolled arrhythmias, hypotension (blood pressure less than 90 / 50 mmHg), uncontrolled hypertension, ischemic stroke within the past 6 months);

With care prescribe medication:

 

— Patients taking alpha 1-blockers.
Simultaneous application (Cialis and alpha 1-blockers) may cause symptomatic hypotension in some patients.

Diagnosis of erectile dysfunction should include:

— Identification of potential underlying cause
— Appropriate medical examination
— Determination of treatment.

Pregnancy and breast-feeding:

Cialis® drug is not intended for use in women.

Side effects:

The most common adverse events in patients with ED are headache and dyspepsia, and back pain, myalgia, flushing, nasal congestion.

The most common adverse events in patients with ED / BPH are headache and indigestion, pain in the limbs, gastroesophageal reflux, myalgia.

 

Immune system: Infrequent (≥0,1%, <1%), hypersensitivity reactions happen.

From the nervous system: very often (≥10%) — headache; frequently (≥1%, <10%) — dizziness; rarely (≥0,01%, <0,1%) — stroke (including acute cerebrovascular accident (CVA) on hemorrhagic type) obmorok1, transient ischemic ataki1, migren3, seizure, transient amnesia.

From the side of view: rare (≥0,1%, <1%) — blurred vision, pain in the eyeball; rarely (≥0,01%, <0,1%) — violation of the visual fields, eyelid swelling, injection of vascular sclera of the eyeball, nearterialnaya anterior ischemic optic neuropathy (NAPION) 3, vascular occlusion setchatki3.

On the part of the organ of hearing and labyrinth disorders: rarely (≥0,01%, <0,1%) — the sudden loss sluha2.

From the CCC: rarely (≥0,1%, <1%) — palpitations, tachycardia, decreased blood pressure (in patients who are already taking antihypertensive agents), increased blood pressure; rarely (≥0,01%, <0,1%) — myocardial infarction, ventricular ritma3, unstable stenokardiya3.

The respiratory system: rarely (≥0,1%, <1%) — nasal congestion, shortness of breath; rarely (≥0,01%, <0,1%) — nosebleeds.

From the gastrointestinal tract: often (≥1%, <10%) — indigestion; infrequently (≥0,1%, <1%) — abdominal pain, gastro-oesophageal reflux.

Skin and subcutaneous tissue disorders: rare (≥0,1%, <1%) — rash, hyperhidrosis (excessive sweating); rarely (≥0,01%, <0,1%) — urticaria, Stevens-Dzhonsona3, exfoliative dermatit3.

 

On the part of the musculoskeletal and connective tissue disorders: frequent (≥1%, <10%) — back pain, myalgia.

On the part of the genital organs and breast cancer: rarely (≥0,01%, <0,1%) — prolonged erection, priapizm3.

General Disorders: Infrequent (≥0,1%, <1%) — pain in grudi1; rarely (≥0,01%, <0,1%) — litsa3 swelling, sudden cardiac smert1,3.

About sudden hearing loss has been reported in a small number of cases. Adverse reactions, identified during post-marketing studies, have not been observed in the placebo-controlled clinical studies.

 

Dosage:

Inside.

Use of the drug Cialis®:

For patients with common sexual activity (more than 2 times per week) recommended frequency of administration — daily one time a day, 5 mg, in one and the same time, regardless of the meal. The daily dose can be reduced to 2.5 mg (depending on individual sensitivity).

For patients with infrequent sexual activity (at least 2 times per week) is recommended: Cialis® 20 mg immediately before sexual activity. Taking the drug is according to instructions. The maximum daily dose is 20 mg Cialis®.

Use of the drug as indicated Sialis® BPH and ED / BPH:

The recommended dose Cialis® when applied 1 time per day is 5 mg. The duration of treatment is determined by the doctor individually.

Patients with renal impairment should get medical advice before taking.

 

 

Overdose:

Symptoms such as side effects
Treatment: symptomatic treatment standard. Tadalafil hardly appear in hemodialysis.

 

 

Where to buy cialis?

You can buy Cialis in pharmacy or order online. Buy generic Cialis online without a prescription can be.

You can buy cheap generic cialis online, using a coupon or discount card.

 

Product:

Film-coated tablets, 5 mg. Table (14) in the blister, consisting of aluminum foil laminated film and PVC / PE / PCTFE. In carton pack — one or two blisters.

Prices for 1-10 tablets of brand Cialis 2.5-20 mg

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