Lasix: Indications for use

Clinico-pharmacological group:

diuretic

Release form, composition and packing:

Tablets white or almost white, round, engraved «DLI» above and below the risk on one side.
Composition: lactose, starch, pregelatinized starch, talc, colloidal silicon dioxide, magnesium stearate.

Active ingredient: furosemide

Lasix is a diuretic. Release form and composition. Dosage Forms: Tablets: round shape, almost white or white on one side above and below the separation risks applied engraving «DLI»

Lasix is a diuretic. Release form and composition. Dosage Forms: Tablets: round shape, almost white or white on one side above and below the separation risks applied engraving «DLI»

Indications for use

— Edema syndrome in patients with chronic heart failure;

— Edema syndrome in patients with chronic renal failure;

— Acute renal failure, including that burns during pregnancy and (to maintain fluid excretion);

— Edema syndrome with nephrotic syndrome (nephrotic syndrome in the foreground is the treatment of the underlying disease);

— Edema syndrome in liver disease (if necessary
addition to the treatment of aldosterone antagonists);

— arterial hypertension.

Contraindications

— Kidney failure with anuria (in the absence of reaction to furosemide);

— Hepatic coma and precoma;

— Severe hypokalemia;

— Severe hyponatremia;

— Hypovolemia (hypotension with or without), or dehydration;

— Pronounced violations of the outflow of urine from any cause (including unilateral urinary tract disease);

— Digitalis intoxication;

— Acute glomerulonephritis;

— Decompensated aortic and mitral stenosis, hypertrophic obstructive cardiomyopathy;

— Increase of central venous pressure (more than 10 mm Hg..);

— Hyperuricemia;

— Children under 3 years of age (the solid dosage form);

— Pregnancy;

— Lactation.
With caution arterial hypotension; a condition in which an excessive reduction of blood pressure is particularly dangerous (constrictive coronary and / or cerebral arteries); acute myocardial infarction (increased risk of cardiogenic shock), latent or manifest diabetes; gout; hepatorenal syndrome; violation of the outflow of urine (prostatic hypertrophy, narrowing of the urethra or hydronephrosis); pancreatitis, diarrhea, ventricular arrhythmia in the history of systemic lupus erythematosus.
Dosage:

General recommendations

1. Tablets should be taken on an empty stomach, without chewing. The tablet is necessary to drink plenty of fluids.
2. Initially, it is recommended to use the lowest dose sufficient to achieve the desired effect.
The maximum recommended daily dose for adults is 1500 mg. The children — 2 mg / kg body weight (no more than 40 mg / day). Duration of treatment is determined individually by your doctor.

Side effects

From the water-electrolyte and acid-base balance:

Hyponatremia, hyposalemia, hypokalemia, hypomagnesemia, hypocalcemia, metabolic alkalosis, which may develop in the form of a gradual rise or electrolyte deficits or massive loss of electrolytes in a very short time, for example, in the case of high-dose furosemide patients with normal renal function. Symptoms indicating the development of disorders of electrolyte and acid-base balance can be a headache, confusion, cramps, tetany, muscle weakness, heart rhythm disorders and dyspepsia. Factors contributing to the development of electrolyte abnormalities are the main diseases (eg, cirrhosis of the liver, or heart failure), concomitant therapy, and poor diet. Hypovolemia (blood volume reduction) and dehydration (often in elderly patients), which may cause hemoconcentration with a tendency to develop thrombosis.

Cardio-vascular system:

Excessive decrease in blood pressure, which, especially in elderly patients may show the following symptoms: impaired concentration and psychomotor reactions, headache, dizziness, drowsiness, weakness, visual disturbances, dry mouth, violation of orthostatic circulatory regulation; collapse.
On the part of the digestive tract:

Rarely — nausea, vomiting, diarrhea, constipation; individual cases of intrahepatic cholestasis, increased liver transaminases, acute pancreatitis.

On the part of the central nervous system, organ of hearing:

In rare cases — hearing loss, usually reversible, and / or ringing in the ears, especially in patients with renal failure or hypoproteinemia (nephrotic syndrome), rarely — paresthesia.

For the skin, allergic reactions:

Rarely — allergic reactions: itching, urticaria, other rashes or bullous skin lesions, erythema multiforme, exfoliative dermatitis, purpura, fever, vasculitis, interstitial nephritis, eosinophilia, photosensitivity. Very rarely — severe anaphylactic or anaphylactoid reactions up to shock, which have hitherto been described only after intravenous administration.