Moduretic — Drug Information: Indications, Side Effects, Warnings

Moduretic represents such medication as diuretics, it is produced in a form of tablets, or pills. Moduretic tablets contain amiloride (5 g) and hydrochlotiaside (50 mg)., thus it is also known as moduretic 50. Moduretic MSD is a combination of diuretic and hypertensive drug, in which strong natriuretic action of hydrochlortiaside and potassuium-saving action of amiloride hydrochloride. This moduretic possesses both, diuretic and hypotensive effects (and that is linked to hydrochlortiaside mostly), while amiloride is needed to prevent excessive loss of potassium which is common side effect of taking thiazide-type diuretics.

Amiloride component of moduretic medication provides not that great loss of magnesium with urine flow compare to monotherapy with thizide-type diuretics or drugs working with Henle’s loop. Mild diuretic and hypotensive effects of amiloride hydrochloride compliment natriuretic, diuretic and hypotensive actions of thiazide, meanwhile reducing to a minimum potassium loss with urine flow, therefore it lessens any possibility of impairment of pH-balance.

Diuretic effect of moduretic drug starts in a two hours and lasts approximately 24 hours. Hydrochlortiaside is more effective if take orally, therefore this medication should be take peroral to reach its peak in four hours. One should remember that hydrochlortiaside does not affect initially normal blood pressure.

Those patients with high blood pressure with suspicions of great potassium loss are advised to take moduretics to prevent it. In monotherapy or in combined therapy one can use as original as generic moduretic. This diuretic can be useful with treating such conditions as hypertension, swelling syndrome of various genesis with chronic cardiac failure, nephrotic syndrome and other kidneys abnormalities, syndrome portal hypertension with cirrhosis.

For treating high blood pressure standard moduretic dosage is just one or two tablets, which can be taken at once or few times a day but by equal doses. For some patients one pill of half-dose moduretic is enough, but for some the standard dosage can be increased yet should not exceed four tablets a day. For swelling caused by heart abnormalities the moduretic therapy can be started with one-two pills daily, optimum dosage should be defined by diuretic effect and potassium level in plasma.

Contradictions include hypewrpotassaemia, anothwer therapy meant to increase potassium level, anuria, renal failure, diabetic nephropathy. Moduretic side effects are mild and may include headache, fatigue, chest pain, back pain, dizziness and nausea, arithmia, tachycardia, orthostatic hypotension, vomiting, diarrhea, abdominal pain, bloating, loss of appetite, hyperkalaemia, rashes, muscular spasms, joints pain.

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