Aldactone (Spironolactone) — Drug Information: Interactions, Side Effects, Warnings

What is aldactone?

Aldacton is another medication which belongs to a class potassium-sparing diuretic, and aldactone generic name is spironolactone. What aldactone is used for? To normalize the diuresis but with preventing potassium excessive excretion, or loss. If you wants to buy aldactone, then you may ask yourself where can I buy aldactone? In fact it can be prescribed by a doctor or it can be bought in the pharmacy or over the counter. Aldactone spironolactone is available in the form of capsules, tablets, and coated tablets. Some pharmacies as well offer to purchase aldactone online on their websites.

Pharmaceutical action of aldactone diuretic

Aldactone medication is potassium-sparing diuretic which action based on being antagonist of aldosterone which stimulates re-absorbtion of sodium in renal tubules and potassium excretion. Aldactone drug is a competitor-antagonist of aldosterone in terms of its influence on distal parts of nephrone, this diuretic compete for the binding sites on the cytoplasmic protein receptors, it reduces permease synthesis at aldosterone-dependent part of collector tubules and distal tubules, increases sodium, chlor, and water excretion, decreases, potassium and urea excretion, reduces titratable acidity of urine. Increased diuresis results in hypotensive effect which is not permanent, diuretis effect can be observed on the second-to-fifth day of such treatment with aldactone for high blood pressure.

What are common indications for aldactone generic and original diuretic?

  • Edema syndrome: chronic congestive heart failure, cirrhosis (especially with presence of hypokalaemia and hyperaldosteronism), nephrotic syndrome, swelling during pregnancy;
  • Primal hyperalsodteronism, or Conn’s syndrome, in such case aldectone medicine should be use as preoperative treatment;
  • Hypokalaemia: preventive treatment with saluretics;
  • High blood pressure: as a part of complex therapy;
  • Adrenic adenoma with aldosterone synthesis: as longpterm supporting therapy in case of no possibility of surgical treatment;
  • Myasthenia: as supporting therapy;
  • Diagnostic of hyperaldosteronism;
  • Hirsutism: use of aldectone hair treatment;
  • Polycystic ovarian syndrome and premenstrual syndrome.

Main contradictions for aldecton spironolactone treatment

  • Hypersensitivity to any of aldactone ingredients;
  • Addison’s disease;
  • Hyperkalaemia;
  • Hypercaliemia;
  • Hyponatiemia
  • Congestive cardiac failure;
  • Anuria;
  • Renal failure;
  • Diabetes with confirmed or suggested congestive heart failure;
  • Diabetic nephropathy;
  • First trimester of pregnancy;
  • Metabolic acidosis;
  • Deprivation of menstrual cycle or breast enlargement.

Partial contradictions include AV-blockade due to the possibility of its intensity increase along with hyperkalaemia, decompensated cirrhosis, surgery, taking medications leading to the gynecomastia development, taking anesthetics, and being of older age.

Aldactone side effects

Such adverse effects of aldactone may include nausea, vomiting, gastritis, ble3eding and ulcers in digestive tract, diarrhea, constipation, dizziness, feeling sleepy, headache, inhibition, ataxy, muscular spasms, lowering potency, increased urea concentration, hypercreatininnemia, hyperuricemia, impairment of water-electrolytes balance, metabolic hypochloremic acidosis, or alcalosis, megaloblastosis, agrunalemia, thrombocytopenia.

It is well known that long-term aldactone uses may lead to a development of so called aldactone gynecomastia, erectile disfunctioning among men, dismenorrhea, amenorrhea, metrorrhagia during climacteric period among women, as well as aldactone hirsutism, voice alteration, painfulness in breast. It is worth to remember that there is some links between using aldactone and breast cancer, in particular, breast carcinoma. Another common aldactone side effect is allergic reactions including urticaria, maculopapular and erythematous rashes, dug fever, itchiness.

Aldactone dosage

It is very important to take adequate aldactone dose to be sure that there won’t be any aldactone adverse side effects. Symptoms of aldactone overdose may include nausea and vomiting, dizziness, diarrhea, skin rashes, hyperkalaemia, parenthesis, myasthenia, arythmia, hyponatriemia with dry mouth being thirsty and sleepiness, hypercaliemia, dehydration, high urea concentration.

How to treat aldactone overdose?

First of all one need to clean the stomach, symptomatic treatment of dehydration and lowering blood pressure. In presence of developed hyperkalaemia urgent dextrose (5-20% solution) and insulin administration, if necessary this action can be repeated.

How to take aldactone and what is proper aldactone dosage?

Aldactone dosage varies depending on the disease being treated and individual characteristics of the patient. To treat cirrhosis with ratio Na+/K+ less then 1 the daily aldactone dose is 100 mg, if such ratio is over 1 then dose should be 200-400 mg. To treat nephrotic syndrome aldactone 100 mg and aldactone 200 mg is required daily combined with thiazide-type diuretics. To treat edema syndrome patient should take aldactone 100 mg/aldactone 200 mg a day divided into two-three doses together with loop or thizide-type diuretics during five days, after that daily dose can be decreased to aldectone 25 mg, or increased to 200-400 mg divided into two-four doses a day. To treat hypokalaemis aldactone 25 mg is required as daily dose but it also can be up to 100 mg at once, yet in certain cases it is better to divide daily dose into few parts.

Is there any food to avoid with taking aldactone, one may ask? Yes, any food rich with potassium should be definitely avoided during aldactone treatment. As well thorough control of renal functions and blood electrolytes is required during treatment.

Aldactone drug interaction

It is known that aldactone spironolactone may lessen the action of indirect anticlotting agents, reduce blood vessels sensitivity towards nor epinephrine, increase T1/2 digoxyn, enforce toxic effects lithium ions. Also aldactone medication is able to accelerate metabolism and carbenoxolone excretion, to reduce effect of heparine, derivatives of cumarine, and of indandion, and toxicity of cardiac glycosides.

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