Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels.
And other synthetic hypoglycemic agents
The nosological classification (ICD-10)
E10 Insulin-dependent diabetes mellitus
E11 Insulin-dependent diabetes mellitus
Applications for use of Acarbose
Acarbose * (Acarbose *). Application: Sugar rafineries type 2 diabetes
Sugar rafineries type 2 diabetes with poor diet (whose rate should not be less than 6 months) or insufficient effectiveness of sulfonylureas on the background of a low-calorie diet; diabetes mellitus type 1 (in combination therapy); Prevention of type 2 diabetes mellitus (patients with impaired glucose tolerance in combination with diet and exercise).
Contraindications of Acarbose
Hypersensitivity, diabetic ketoacidosis, cirrhosis of the liver; acute and chronic inflammatory bowel disease complicated with impaired digestion and absorption (including malabsorption syndrome, maldigestion syndrome); Remgelda syndrome, major hernias of the abdominal wall, the pathology of the gastrointestinal tract with flatulence, ulcerative colitis, intestinal obstruction (including partial or predisposition to it), strictures, and bowel ulcers, chronic renal failure (creatinine above 2 mg / dl), pregnancy, lactation. Fever, infection, injury, surgery, pre- and postoperative periods, up to age 18 years (safety and efficacy of the children are not identified).
Hypersensitivity, diabetic ketoacidosis, cirrhosis of the liver; acute and chronic inflammatory bowel disease complicated with impaired digestion and absorption (including malabsorption syndrome, syndrome maldigestion) Remhelda syndrome; pathology of the gastrointestinal tract with flatulence, ulcerative colitis, intestinal obstruction, including partial or predisposition to it, strictures, and bowel ulcers, hernias larger, chronic renal insufficiency (creatinine above 2 mg / dl), pregnancy, breast-feeding.
Restrictions apply of Acarbose
If fever, infection, trauma, surgery (upcoming surgery and in the postoperative period) the application is only possible if the expected effect outweighs the potential risk. Age 18 years (Safety and efficacy have not been determined).
Pregnancy and breast-feeding
Safety of use in pregnancy has not been established.
Category effects on the fetus by FDA — B.
At the time of treatment should stop breastfeeding.
Side effects of Acarbose
Co the digestive tract: abdominal pain, flatulence, nausea, diarrhea; rare — increase in transaminases (ALT and AST), ileus, jaundice, hepatitis (in isolated cases fulminant fatal).
Allergic reactions: skin rash, flushing, rash, urticaria.
Other: rarely — swelling.
Symptoms: increased discomfort in the abdomen, diarrhea, flatulence.
Treatment: to eliminate from the diet foods and drinks containing carbohydrates (at least 4-6 hours)
Dosage of Acarbose
Inside, at the beginning of the meal; initial dose — 50 mg three times a day. Increasing the dose of 100-200 mg three times a day, it is performed with 4-8 week intervals, based on two criteria — the blood glucose level at 1 hour after eating and individual tolerability. The usual dose for adults weighing 60 kg, and less than — 50 mg, body weight over 60 kg — 100 mg 3 times a day. The maximum dose — 600 mg / day. Prevention: an initial dose — 50 mg 1 time per day with gradual increase in single doses up to 100 mg (dose increase is carried out within 3 months).